bile acid


Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia.
Related to bile acid: bile salt

bile acid

n.
Any of the liver-generated steroid acids, such as cholic acid, that commonly occur in the bile in combination with glycine and taurine as sodium salts.

bile acid

Either of several acids—e.g., cholic acid (CA), chenodeoxycholic acid (CDA)—which are formed in the liver and converted by intestinal bacteria into deoxycholic acid (from CA) and lithocholic acid (from CDA), which are known as secondary BAs. BAs are conjugated in the liver to glycine or taurinese conjugates; glycocholic acid and taurocholic acid form sodium and potassium salts in the alkaline bile in the liver. These conjugated bile acids have a central role in the emulsification and absorption of fatty acids.

Specimen
Serum.
 
Ref range
< 60 µg/mL—as cholylglycine.
 
Method
RIA.
References in periodicals archive ?
These concentrations were approximately 1000-fold higher than the urinary excretion of 3[beta]-sulfated-[[DELTA].sup.5]-cholenoic acids in noncholestatic liver disease patients with healthy primary bile acid synthesis [5.9 (0.2) [micro]mol/L, n = 7], idiopathic cholestatic liver disease patients with increased primary bile acid synthesis [7.8 (2.3) [micro]mol/L, n = 5], and healthy children [0.13 (0.12) [micro]mol/L, n = 6].
Jatrorrhizine promoted the conversion of cholesterol to bile acids and the excretion of bile acids by feces
The patients with ICP were categorized into two groups according to their serum bile acid levels: mild (<40 [micro]mol/L, n=53) and severe ([greater than or equal to]40 [micro]mol/L, n=31).
Although some bile acids have been identified as the most important bioactive constituents in CBS, the actual pharmacologically active components have not been determined yet [7].
Cholesterol and bile acid were extracted according to Carr's method.
Results from the Phase 2 study in pediatric cholestasis were presented on the effect of odevixibat on reducing serum bile acids, and improving pruritus and sleep measures in a subset of patients with Alagille syndrome, as well as the effect of odevixibat on reducing serum bile acids and improving pruritus in a small subset of patients with biliary atresia.
A clinical drug trial will be starting in early 2020 using rifampicin, an antibiotic that is also an effective treatment for itch outside pregnancy and improves removal of bile acids from the bloodstream.
Under the company's prior Phase 2 INDIGO clinical trial, the blocking bile acid transport from the intestine to the liver with maralixibat resulted in profound and durable reductions in serum bile acids (sBA), clinically meaningful improvements in pruritus and acceleration of growth in some patients with PFIC2.
Elevated colonic concentrations of the primary bile acid chenodeoxycholic acid (CDCA) or the secondary bile acid deoxycholic acid (DCA) are known to induce water secretion, causing diarrhea.
Veterinarians should consider the CA and bile acid limitations of the Avian/ Reptilian Profile Plus reagent rotor when sampling laying hens.