bilateral prophylactic oophorectomy

bilateral prophylactic oophorectomy

The surgical excision of both ovaries in a woman at an increased risk of breast cancer because she carries the BRCA1 mutation, an effect attributed to reduction of ovarian hormone exposure.
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Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group.
It is interesting that some of these patients underwent bilateral prophylactic oophorectomy (BPO) and multivariate Cox analysis suggested that this led to a significant benefit in overall survival at 5 years.
Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers.
While bilateral prophylactic oophorectomy offers protection against ovarian cancer, this option is limited to women beyond child-bearing age, some of whom do not consider this desirable outcome.
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