sup], Contrastly, extracellular serine protease inhibitors, such as aprotinin and bikunin
, have been shown to decrease channel activity.
OS upregulates the expression of various factors, including bikunin
, osteopontin (OPN), and the Tamm-Horsfall protein, and activates the p38 mitogen-activated protein kinase (MAPK) pathway.
Ulinastatin is also called urinary trypsin inhibitor (UTI), HI-30, or bikunin
Se han descrito inhibidores multidominios de la familia BPTI/ Kunitz, como el bikunin
(Zhuo et al.
The paper is titled "The proteoglycan bikunin
has a defined sequence.
Suppression of urokinase expression and tumor metastasis by bikunin
Exposure of renal epithelial cells to CaOx crystals results in the increased synthesis of osteopontin, bikunin
, heparan sulphate, monocyte chemoattractant protein (MCP)-l, and prostaglandin (PG) E2, which are known to participate in inflammatory processes and in extracellular matrix production.
Immunohistochemical demonstration of bikunin
, a light chain of inter-[alpha]-trypsin inhibitor, in human brain tumors.
is the active subunit of protein/carbohydrate complexes that together comprise the inter-[alpha]inhibitor protein family, which plays a major role in extracellular matrix stability and integrity (Bost et al.
Finally, the use of recombinant bikunin
as a xylose acceptor enabled an accurate and sensitive determination of XT-I activity, even in human serum (13,14).
as a favorable prognostic factor in ovarian cancer.
Unlike other members of the inter-[alpha]-trypsin inhibitor family (12, 13), ITIH4 is present in plasma as a single-chain protein because its COOH terminus lacks the consensus sequence (DPHFII) for bikunin
assembly through the glycosaminoglycan bridges (2, 3, 12-14).