biglycan


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bi·gly·can

(bī'glī-kan), [MIM*301870]
A small interstitial proteoglycan that contains two glycosaminoglycan chains.
Synonym(s): proteoglycan I

biglycan

A small leucine-rich repeat (LRR) proteoglycan encoded by BGN on chromosome Xq28, which plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.

biglycan

a small chondroitin sulfate proteoglycan found in mineralized bone.
References in periodicals archive ?
S)-[6]-Gingerol inhibits TGF-beta-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells.
Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lurnican, and fibromodulin.
5) Nevertheless, there are currently no studies on the immunoexpression of biglycan and decorin in primary teeth.
In experiments described in the paper, Fallon's team showed that biglycan delivered to the bloodstream draws utrophin to the cellular membranes of muscle cells.
Candidate polysaccharide or proteoglycan subunits include aggrecan, agrin, bamacan, heparan sulfate, chondroitin sulfate, keratan sulfate, versican, phosphocan, perlecan, hyaluronan, decorin, dermatan sulfate, biglycan, fibromodulin, alginate, polylactate, polyglycolic acid, starch, dextran, agarose, chitan, chitosan, and heparin.
Accumulation of Biglycan and Perlecan, but not Versican, in lesions of murine models of atherosclerosis.
ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan.
anemone) using human proteins implicated in wound healing as the initial query Human query ID Nematostella E hit value Signaling Integrin, alpha 8 NM_003638 XM_001641385 1e-79 Integrin, alpha 4 NM_000885 XM_001641385 1e-74 TGF-beta type I AAD02042 XM_001622484 7e-138 receptor JNKI-B1 NM_139046 XM_001637538 3e-133 SLRPs (small leucine-rich-repeat proteins) Biglycan AAA52287 XM_001639122 9e-17 Chondroadherin AAK51556 XM_001639122 4e-22 Decorin AAB60901 XM_001633690 2.
Two sequence-specific peptide antisera (LF-15 and LF-30) generated against synthetic peptides corresponding to amino acids 11-24 and 5-17 of the human core proteins of 2 small leucine-rich proteoglycans, biglycan and decorin, were used to characterize territorial or interterritorial cartilage matrices.
Scientists at the National Institute of Dental and Craniofacial Research (NIDCR) have created mice that genetically mimic many of the signs of osteoporosis, at least in the sense that the mice lack the gene responsible for coding the bone strengthening protein biglycan.
Funding Supplements Tivorsan Pharmaceuticals' Commercialization Efforts of Biglycan as Novel Disease-Modifying Therapeutic
Feng, "NF-[kappa]B protects human neuroblastoma cells from nitric oxide-induced apoptosis through upregulating biglycan," American Journal of Translational Research, vol.