Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded under voltage-clamp at -70 mV from CA1 pyramidal neurons after blocking the GABAA receptors by using 30 [micro]M bicuculline
Prenatal exposure to the pesticide dieldrin or the GABAA receptor antagonist bicuculline
differentially alters expression at GABAA receptor subunit mRNAs in fetal rat brainstem.
2002) Behavioral consequences of bicuculline
injection in the subthalamic nucleus and the zona incerta in rat.
Even when the food was at a safe distance from the robot, rats treated with the drug bicuculline
, which increases neural activity, were too afraid to venture out for the pellet.
Consistently, Kimura (1994) showed that intravenous infusion of bicuculline
, a GABAA receptor antagonist, on the morning of proestrus induced a premature surge-like secretion of LH (23).
A calcium channel antagonist stereoselectively decreases ethanol withdrawal hyperexcitability but not that due to bicuculline
, in hippocampal slices.
Haloperidol inhibits (-) bicuculline
-induced seizures and bicuculline
potentiates haloperidol-induced catalepsy in mice.
Identification of differential gene expression profiles in rat cortical cells exposed to the neuroactive agents trimethylolpropane phosphate and bicuculline
In various experiments these included bicuculline
, picrotoxin, Ro15-1788 (flumazenil) and delta-amino-n-valeric acid (Leslie, Shephard, & Toal, 1994; Shephard, Toal, & Leslie, 1990; Toal, Leslie, & Shephard, 1991).
Moreover, seizures induce IL-1 (3 release in cortex and hippocampus in bicuculline
rat model and further cause blood-brain barrier damage with protein extravasation (Li et al.
Antagonism of [gamma]-aminobutyric acid (GABA) receptors with bicuculline
(BIC) phenocopied the dendrite-promoting effects of PCB-95, and pharmacological antagonism or siRNA knockdown of RyR blocked BIC-induced dendritic growth in dissociated and slice cultures of hippocampal neurons.
and flumazenil purchased from Sigma Aldrich (St.