In postsynaptic buccal cells, B34 and B40 produce chloride-mediated rapid inhibitory postsynaptic potentials (IPSPs) that are desensitized by GABA and the [GABA.sub.A] agonist muscimol, blocked by the [GABA.sub.A] antagonists picrotoxin and bicuculline
, and augmented by the GABA uptake inhibitor nipecotic acid (Jing et al., 2003).
Progesterone, ALLO, 5[alpha]-DHP, 6-hydroxydo pamine hydrobromide (6-OHDA), amphetamine, desipramine HCl, bicuculline
, apomorphine hydrochloride, and NADPH were purchased from Sigma-Aldrich (St.
Although networks can have different levels of spontaneous activity, the use of the internal reference results in highly reproducible pharmacological responses [18, 23, 28-32] and even allows calculation of dissociation constants .The reference is either native activity (i.e., activity recorded prior to application of any compound) or a stable reference state under a constant additive, such as bicuculline
, which was used in ~60% of the experiments to increase activity and stabilize the minute mean profile.
Prenatal exposure to the pesticide dieldrin or the GABAA receptor antagonist bicuculline
differentially alters expression at GABAA receptor subunit mRNAs in fetal rat brainstem.
(2002) Behavioral consequences of bicuculline
injection in the subthalamic nucleus and the zona incerta in rat.
Even when the food was at a safe distance from the robot, rats treated with the drug bicuculline
, which increases neural activity, were too afraid to venture out for the pellet.
Consistently, Kimura (1994) showed that intravenous infusion of bicuculline
, a GABAA receptor antagonist, on the morning of proestrus induced a premature surge-like secretion of LH (23).
[GABA.sub.A] receptors are sensitive to bicuculline
and insensitive to baclofen, [GABA.sub.B] receptors are insensitive to bicuculline
and sensitive to baclofen, [GABA.sub.C] receptors are insensitive to both bicuculline
and baclofen (Hill & Bowery, 1981, Drew, Johnston, & Weatherby, 1984; Krogsgaard-Larsen P., Frolund, B.
A calcium channel antagonist stereoselectively decreases ethanol withdrawal hyperexcitability but not that due to bicuculline
, in hippocampal slices.
Haloperidol inhibits (-) bicuculline-induced seizures and bicuculline
potentiates haloperidol-induced catalepsy in mice.