Biclonal gammopathy | definition of biclonal gammopathy by Medical dictionary
a gammopathy in which the serum contains two distinct monoclonal immunoglobulins.
biclonal gammopathy The presence of 2 clonal expansions—IgG > IgA > IgM—in the same patient. Two-thirds of biclonal gammopathies are of undetermined significance; one-third are associated with myeloma or lymphoproliferative disorders, including lymphomas and leukaemias.
biclonal gammopathy Oncology The presence of 2 clonal expansions–IgG > IgA > IgM, in the same Pt;2⁄3 of BGs are of undetermined significance;1⁄3 are associated with myeloma or lymphoproliferative disorders, including lymphomas and leukemias. Cf Monoclonal gammopathy of undermined significance.
References in periodicals archive
Chronic lymphocytic leukemia with associated lambda-light-chain and IgG lambda paraproteins simulating a biclonal gammopathy
is associated with similar disorders (5) The distribution between various clinical entities, the clinical features of the patients as well as the prognosis seem to be similar to those of monoclonal gammopathies (6).
Pseudotumoral lesions involving the mammary glands, the liver, or the spleen and, recently, glomerulonephritis and cases of monoclonal and biclonal gammopathy
have also been associated with B.