Composite low grade B-cell lymphomas with two immunophenotypically distinct cell populations are true
biclonal lymphomas: a molecular analysis using laser capture microdissection.
Clinical characteristics and outcomes in
biclonal gammopathies.
Another possible mechanism to be considered is the presence of
biclonal population of tumor cells, with one clone harboring KRAS mutation and the other clone harboring BRAF mutation.
Almost four months after HCT, she developed progressive pancytopenia,
biclonal gammopathy, and IGH gene rearrangement.
Possible explanations may include a synchronous
biclonal origin (collision tumor) [10] and bidirectional or metaplastic differentiation of a single clone of totipotential cancer cells [4, 6, 9, 15].
Juge-Morineau et al analysed the immunoglobulin heavy chain V-region (Ig HV) genes of three IgD, one IgM, and one
biclonal (IgG and IgM) multiple myeloma for the presence of somatic mutations based on molecular analysis of the Ig HV.
(1)
Biclonal gammopathy, defined as the simultaneous appearance of two different monoclonal protein components, is rare.
A surgical case of solitary plasmacytoma of rib origin with
biclonal gammopathy.
Betticher, "Myelodysplastic syndrome with
biclonal monosomy 7 and trisomy 8 after treatment with cladribine (2-chloro-2deoxyadenosine) and involved field radiation therapy," Cancer Genetics and Cytogenetics, vol.
Pfeifer et al., "
Biclonal origin prevails in concomitant chronic lymphocytic leukemia and multiple myeloma," Leukemia, vol.
Under the continual stimulus of estrogen and progesterone, the smooth muscle cells continue to proliferate, eventually becoming
biclonal or monoclonal as individual cell types with growth advantages emerge.