biallelic

biallelic

adjective Referring to 2 alleles.
References in periodicals archive ?
Spark's lead candidate, Luxturna is indicated as a potential one-time gene therapy for the treatment of patients with vision loss due to confirmed biallelic RPE65-mediated inherited retinal dystrophies, a group of rare blinding conditions caused by one of more than 220 different genes.
The FDA has granted approval to the investigational adeno-associated viral (AAV) vector gene therapy as a one-time gene therapy for confirmed Biallelic RPE65 mutation-associated retinal dystrophy.
Biallelic alterations of the large tumor suppressor 1 (LATS1) gene in infiltrative, but not superficial, basal cell carcinomas in a Japanese patient with nevoid basal cell carcinoma syndrome.
The company, which specialises in gene therapy for the treatment of rare, inherited retinal diseases, said that the main objective will be to establish the safety and efficacy of a unilateral subretinal injection of the product in patients with a retinitis pigmentosa caused by biallelic mutations in the PDE6B gene, which can lead to a defective expression of the PDE6B protein (PDE6beta).
Biallelic mutations in BRCA1 cause a new Fanconi anaemia subtype.
The MS markers are likely to be used continuously in the future since they are comparatively cheap for genotyping and provide more genetic information on population than biallelic markers such as single nucleotide polymorphisms [6].
The findings, led by Jordi Surralles, Professor at the University at Autonoma de Barcelona, showed that the genetic syndrome is caused by mutations in both copies of the FANCM gene - also known as biallelic mutations.
demonstrated that biallelic inactivation of TOX and PRKCD was recurrently found in PCNSL but not in systemic DLBCL; additionally, 90% of all cases harbored mutations leading to activation of the NF-?
Now a days, CRISPR/Cas9 system efficiency has been improved for biallelic gene interference in F0 population of zebrafish.
Because several commonly used relatedness estimators can be problematic when used with biallelic loci (Oliehoek et al.
The diagnosis of MPAN is confirmed only in individuals with biallelic pathogenic variants in C19orf12, the only gene in which pathogenic variants are known to cause the condition.