Olson also believes recent competitor studies in NASH increase the scarcity value of Intercept's registrational asset, and thinks MRI-PDFF results for seladelpar have no impact on Intercept's plans to study a combination of OCA plus bezafibrate
WEDNESDAY, June 13, 2018 (HealthDay News) -- Nearly one-third of patients with primary biliary cholangitis who had had an inadequate response to ursodeoxycholic acid alone achieved a complete biochemical response with the addition of bezafibrate
to treatment, according to a study published online June 7 in the New England Journal of Medicine.
In SA, bezafibrate
and fenofibrate are the best-known fibrates.
Additionally, similar results are found when comparing PFOA to other PPAR[alpha] agonists clofibrate, bezafibrate
, fenofibrate and gemfibrozil (see Tab.
The patient had coronary risk factors, including hypertension, dyslipidemia, family history of coronary disease, and past history of smoking, and was taking medication prescribed by his regular physician (nifedipine 20mg/day for hypertension; bezafibrate
400mg/day for hyperlipidemia).
Da Costa et al  investigated the occurrence of emergent contaminants at five sampling points along Paranoa Lake, including the point at the lake dam, where they observed lower concentrations of caffeine, bezafibrate
, bisphenol A, diethyl phthalate, and nonylphenol compared to the other points located in the four branches of the lake.
Pure standards (>98%) of ketoprofen (KET), ibuprofen (IBU), bezafibrate
(BF), triclosan (TCS), triclocarban (TCC), chloramphenicol (CAL), norfloxacin (NOR), ofloxacin (OFL), ciprofloxacin (CIP), acetaminophen (ACE), atenolol (ATE), tetracycline (TCN), diclofenac salt (DIC), estrone (E1), 17[beta]-estradiol (E2), estriol (E3), and 17[alpha]-ethinylestradiol (EE2) were all purchased from Sigma-Aldrich (Aston Manor, South Africa).
Interestingly, the pan-PPAR agonist bezafibrate
was shown to reduce tau phosphorylation in a P301 mice model by reducing iNOS and cyclooxygenase-2 in microglia .
Okopien, "The effect of bezafibrate
and omega-3 fatty acids on lymphocyte cytokine release and systemic inflammation in patients with isolated hypertriglyceridemia," European Journal of Clinical Pharmacology, vol.
, a nonselective PPAR (A, D/B, and G) agonist, regulates energy homeostasis by the upregulation of PPARa and UCP-1, 2, and 3 [113, 114].
The fibrate drug bezafibrate
was found in one study to reduce the incidence and delay the onset of type II diabetes in subjects with impaired fasting glucose.
Infarction Prevention (BIP)study.