bexarotene


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bexarotene

 [bek-sar´ah-tēn]
a retinoid that modulates transcription and expression of genes involved in cellular differentiation and proliferation; used as an antineoplastic in the treatment of cutaneous T-cell lymphoma, administered orally. It is also used topically in the treatment of cutaneous lesions of T-cell lymphomas and Kaposi's sarcoma.

bexarotene

A retinoid that binds to retinoid X receptors, upregulating their activity by either removing negative transcription control or by facilitating transcription. It is FDA-approved for treating cutaneous T cell lymphoma, and has been used off label for lung and breast cancer, and Kaposi sarcoma.
Adverse effects Similar to hypervitaminosis A—headache, nausea, vomiting, lip inflammation, mucous-membrane dryness, joint pain, scaly skin, hyperlipidaemia
References in periodicals archive ?
They are hydromorphone oral solution, hydromor-phone tablets, dronabinol capsules and bexarotene capsules.
Treatment includes topical steroids, mechlorethamine (nitrogen mustard) or bexarotene gel, PUVA therapy, and narrow band UVB light for limited and/ or patch disease.
Pharmaceutical company Upsher-Smith Laboratories LLC reported on Thursday the availability of Bexarotene Capsules in 75 mg under its growing generic portfolio of product offerings.
Six additional chemicals (rafoxanide, lasalocid sodium, 2,2'-methylenebis(4-methyl-6-tert-butylphenol, 2,2'-methylenebis(ethyl6-tert-butylphenol), 2-hydrazino-4-phenylthiazole, and bexarotene) had LECs [less than or equal to] 10 [micro]M for the larval growth assay with lower potency or inactivity in the ATP assay, which is suggestive of general toxicity.
The researchers discovered that bexarotene stimulates the production of another protein, APOE, which the study showed was capable of dissolving the platelets that lead to the symptoms of the disease.
Bexarotene is a new treatment option for lymphomatoid papulosis.
Ardizzoni, "Hypertriglyceridaemia with bexarotene in cutaneous T cell lymphoma: The role of omega-3 fatty acids," British Journal of Haematology, vol.
The third-generation retinoids are the polyaromatics (bexarotene, adapalene, and tazarotene) [157, 158].
The localized lesions of PC-ALCL can be treated with excision, low-dose methotrexate, topical corticosteroids, topical mechlorethamine, oral antibiotics, phototherapy, interferon alfa, and systemic retinoids, including bexarotene. Chemotherapy is not recommended because it does not prevent recurrence and has many adverse effects (9).
Consideremos, por ejemplo, un informe de Science de 2012 que muestra que un medicamento para el Alzheimer llamado bexarotene reduciria la placa beta-amiloidea en cerebros de raton.
The exclusion criteria were: having depression associated with an organic disorder; other psychotic disorders besides schizophrenia; comorbidity with substance dependence or abuse; concomitant use of lithium, potassium iodine, amiodarone, dopamine, prednisone, somatostatin and bexarotene analogues.