betulinic acid

A natural pentacyclic triterpene extracted from bark of various plants—e.g., Betula pubescens, Lycopus lucidus, Syzigium claviflorum, Ziziphus mauritiana, Prunella vulgaris, and others—which is anti-retroviral (inhibits steps of HIV assembly and virion budding), anti-malarial, anti-inflammatory and anti-proliferative (inhibits telomerase and induces apoptosis).

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Keywords: Betulinic acid; Triterpene; Organotin(IV) Complex; Antimicrobial activity; Antioxidant activity.

Synthesis, Spectral Characterization and Biological Evaluation of Organotin(IV) Complexes of Aniline Derivatives of Naturally Occurring Betulinic Acid

Betulinic acid (3-hydroxy-lup-20 (29)-en-28-oic acid)10 structurally speaking is a pentacyclic lupine type compound belonging to a class named triterpenoid which is distributed broadly in the plant kingdom.

Comparative Study of Betulinic Acid Versus Simvastatin on Total Cholesterol and HDL in Hyperlipidemic Model

Analyte Mass data [t.sub.R] (min) Ion mode Spinosin 608.1741 2.40 ES[I.sup.-] 6"'-Feruloylspinosin 784.2215 2.54 ES[I.sup.-] Jujuboside A 1207.3533 2.75 ES[I.sup.-] Jujuboside B 1044.5505 2.83 ES[I.sup.-] Camelliaside B 726.2007 2.36 ES[I.sup.-] Betulinic acid 456.3604 5.16 ES[I.sup.-] Analyte M[S.sup.1] (m/z) M[S.sup.2] (m/z) Spinosin 607.10 427.10 6"'-Feruloylspinosin 783.40 427.20 Jujuboside A 1206.60 1073.30 Jujuboside B 1043.60 911.40 Camelliaside B 725.30 284.00 Betulinic acid 455.30 455.30 Analyte DP/V CE/eV Spinosin -26.46 -41.60 6"'-Feruloylspinosin -25.83 -50.92 Jujuboside A -60.00 -60.00 Jujuboside B -27.20 -49.77 Camelliaside B -23.72 -53.07 Betulinic acid -97.00 -20.00 TABLE 2: Calibration curves, correlation coefficients (r), and linear ranges of the six components.

Simultaneous Quantification of Six Bioactive Components in Decoction of Ziziphi spinosae Semen Using Ultrahigh Performance Liquid Chromatography Coupled with Triple-Quadrupole Mass Spectrometry

Therefore, helicteric acid (HA), oleanic acid (OA), and betulinic acid (BA) were selected for our experiments and extracted from HT according to our previous study [24].

Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-[kappa]B and STAT3 Signaling

Borska et al., "The new esters derivatives of betulin and betulinic acid in epidermoid squamous carcinoma treatment*-in vitro studies," Biomedicine and Pharmacotherapy, vol.

Betulin-Based Oleogel to Improve Wound Healing in Dystrophic Epidermolysis Bullosa: A Prospective Controlled Proof-of-Concept Study

Scheffler, "Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L," Planta Medica, vol.

Synergistic Antitumour Properties of viscumTT in Alveolar Rhabdomyosarcoma

fruit extract and quantification of betulinic acid by HPLC," Phytomedicine, vol.

Appraisals of Bangladeshi medicinal plants used by folk medicine practitioners in the prevention and management of malignant neoplastic diseases

Water stress (waterlog and drought) increase betulinic acid and phenolic compounds in Hypericumbrasiliense[7].

Water stress affecttotal phenolic content and antioxidant capacity of Orthosiphon stamineus leaf and stem

Betulinic acid, isolated from Vitis amurensis root, attenuates melanin production by inhibiting tyrosinase, tyrosinase-related protein (TRP)-l and TRP-2 expression through the modulation of their corresponding transcription factors.

Formulating cosmeceuticals & nutraceuticals for skin care: innovative ingredients from time-tested natural sources await commercialization in nutritional and topical products for an inside-outside strategy

Betulinic acid is a pentacyclic triterpenoid with reported antiretroviral, antimalarial and anti-inflammatory activity and anticancer properties extracted from the bark of Betula pubescens (53), (54).

An in silico based comparison of drug interactions in wild and mutant human [beta]-tubulin through doclqing studies

Sriram, "Betulinic acid and its derivatives: a review on their biological properties," Current Medicinal Chemistry, vol.

Antibacterial activity of Mulinum spinosum extracts against slime-producing Staphylococcus aureus and methicillin-resistant Staphylococcus aureus isolated from nasal carriers

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