Keywords:
Betulinic acid; Triterpene; Organotin(IV) Complex; Antimicrobial activity; Antioxidant activity.
Betulinic acid (3-hydroxy-lup-20 (29)-en-28-oic acid)10 structurally speaking is a pentacyclic lupine type compound belonging to a class named triterpenoid which is distributed broadly in the plant kingdom.
Analyte Mass data [t.sub.R] (min) Ion mode Spinosin 608.1741 2.40 ES[I.sup.-] 6"'-Feruloylspinosin 784.2215 2.54 ES[I.sup.-] Jujuboside A 1207.3533 2.75 ES[I.sup.-] Jujuboside B 1044.5505 2.83 ES[I.sup.-] Camelliaside B 726.2007 2.36 ES[I.sup.-]
Betulinic acid 456.3604 5.16 ES[I.sup.-] Analyte M[S.sup.1] (m/z) M[S.sup.2] (m/z) Spinosin 607.10 427.10 6"'-Feruloylspinosin 783.40 427.20 Jujuboside A 1206.60 1073.30 Jujuboside B 1043.60 911.40 Camelliaside B 725.30 284.00
Betulinic acid 455.30 455.30 Analyte DP/V CE/eV Spinosin -26.46 -41.60 6"'-Feruloylspinosin -25.83 -50.92 Jujuboside A -60.00 -60.00 Jujuboside B -27.20 -49.77 Camelliaside B -23.72 -53.07
Betulinic acid -97.00 -20.00 TABLE 2: Calibration curves, correlation coefficients (r), and linear ranges of the six components.
Therefore, helicteric acid (HA), oleanic acid (OA), and
betulinic acid (BA) were selected for our experiments and extracted from HT according to our previous study [24].
Borska et al., "The new esters derivatives of betulin and
betulinic acid in epidermoid squamous carcinoma treatment*-in vitro studies," Biomedicine and Pharmacotherapy, vol.
Scheffler, "Solubility studies of oleanolic acid and
betulinic acid in aqueous solutions and plant extracts of Viscum album L," Planta Medica, vol.
fruit extract and quantification of
betulinic acid by HPLC," Phytomedicine, vol.
Water stress (waterlog and drought) increase
betulinic acid and phenolic compounds in Hypericumbrasiliense[7].
Betulinic acid, isolated from Vitis amurensis root, attenuates melanin production by inhibiting tyrosinase, tyrosinase-related protein (TRP)-l and TRP-2 expression through the modulation of their corresponding transcription factors.
Betulinic acid is a pentacyclic triterpenoid with reported antiretroviral, antimalarial and anti-inflammatory activity and anticancer properties extracted from the bark of Betula pubescens (53), (54).
Sriram, "
Betulinic acid and its derivatives: a review on their biological properties," Current Medicinal Chemistry, vol.