beta2 microglobulin

beta2 microglobulin



A polypeptide that is one of the class I major histocompatibility markers on cell surfaces; it is grouped into chains of low molecular weight called light chains. The ß2-m chain may be affected by the nef gene in HIV, preventing CD8+ T lymphocytes from recognizing the virus.
See: acquired immunodeficiency syndrome; major histocompatibility complex


any globulin, or any fragment of a globulin, of low molecular weight.

β2 microglobulin
a polypeptide found free in serum and which also combines with the α (heavy) chain to form class I major histocompatibility heterodimer. See also major histocompatibility complex.
References in periodicals archive ?
Prognostic markers like beta2 microglobulin and Interleukin-6 (IL-6) are not available in most centres in developing countries like India.
The cerebrospinal fluid and plasma concentrations of gamma-trace beta2 microglobulin at various ages and in neurological disorders.