beta2 microglobulin

beta2 microglobulin



A polypeptide that is one of the class I major histocompatibility markers on cell surfaces; it is grouped into chains of low molecular weight called light chains. The ß2-m chain may be affected by the nef gene in HIV, preventing CD8+ T lymphocytes from recognizing the virus.
See: acquired immunodeficiency syndrome; major histocompatibility complex


any globulin, or any fragment of a globulin, of low molecular weight.

β2 microglobulin
a polypeptide found free in serum and which also combines with the α (heavy) chain to form class I major histocompatibility heterodimer. See also major histocompatibility complex.
References in periodicals archive ?
Major Companies Developing or Marketing Beta2 Microglobulin Tests
The cerebrospinal fluid and plasma concentrations of gamma-trace beta2 microglobulin at various ages and in neurological disorders.
Germany, Beta2 Microglobulin Test Volume And Diagnostics Sales Forecast by Market Segment
France, Beta2 Microglobulin Test Volume and Diagnostics Sales Forecast by Market Segment
This technology may be used as a vaccine to generate immunity to the HIV virus by stimulating antibodies to beta2 microglobulin (B2m), which is a cellular antigen that is common in high concentrations to all known strains of the virus.