BACE2

(redirected from beta-site APP-cleaving enzyme 2)

BACE2

A gene on chromosome 21q22.3 that encodes beta secretase 2, a transmembrane enzyme responsible for the proteolysis of the amyloid precursor protein, leading to the generation and extracellular release of beta-cleaved soluble AP. It is expressed at low levels in most peripheral tissues and at higher levels in the colon, kidney, pancreas, placenta, prostate (in benign and malignant ducts), stomach and trachea.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Gene ID Gene symbol Gene description 78963 Apaf1 Apoptotic peptidase activating factor 1 288227 Bace2 Beta-site APP-cleaving enzyme 2 25031 Plcb4 Phospholipase c, beta 4 Gene ID [log.sub.2] (ratio) P value 78963 -1.0464 0.00267 288227 -1.0448 0.00001 25031 -1.0673 0.00381 FIGURE 3: The results of GO classification in ME pretreatment group.