He found that Alzheimer's beta-secretase
, BACE1, which triggers amyloid pathology, cleaves glycosyltransferases and controls glycan expression.
Increased Plasma Beta-Secretase
1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.
, APP and Abeta in Alzheimer's disease.
Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1alpha regulated beta-secretase
1 degradation and mitochondrial gene expression in Alzheimer's mouse models.
In addition, another drug being developed focuses on beta-secretase
(BASE), a compound that makes it possible for beta-amyloid to form.
Also, the companies are collaborating in the development and commercialization of a beta-secretase
1 inhibitor program in AD.
APP's cleavage is done first by beta-secretase
, followed by a second cleavage by the gamma-secretase complex.
(35.) Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P Beta-secretase
cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
An enzyme called beta-secretase
(BACE)--which is involved in the formation of beta-amyloid protein, a hallmark of AD--may be responsible for the AD-seizure connection, according to researchers at the MassGeneral Institute for Neurodegenerative Disorders (MGH-MIND).
The product is an oral beta-secretase
1 cleaving enzyme inhibitor.
Food and Drug Administration (FDA), the FDA confirmed there was sufficient data to support the advancement of its novel investigational oral beta-secretase
cleaving enzyme (BACE) inhibitor E2609 into Phase III clinical studies.
San Diego, CA, February 19, 2016 --(PR.com)-- Jared Cumming, Director, Global Chemistry at Merck, will give a distinguished speaker presentation on, "Discovery of Verubecestat (MK-8931): A beta-Secretase
Inhibitor in Phase 3 Clinical Development for Alzheimer's Disease" at GTCbio's 2nd Protease Inhibitors in Drug Discovery Conference to be held on March 1-2, 2016 in San Diego, CA.