beta-secretase

beta-secretase

(bā-tă-sē-krĕ-tāz),
Agent that exists in two isoforms; protein with homology to the pepsin family of aspartyl proteases involved in the cleavage of beta-amyloid precursor protein; the gene for this protein is located on chromosome 11.
Farlex Partner Medical Dictionary © Farlex 2012

BACE1

B-site amyloid precursor protein (APP) cleaving enzyme. An aspartic-acid protease encoded by BACE1 on chromosome 11q23.2.-q23.3, which is linked to the pathogenesis of Alzheimer's disease and the formation of myelin sheaths in peripheral nerve cells. BACE1 is a transmembrane aspartic protease (beta-secretase) found in the Golgi apparatus, trans-Golgi network, secretory vesicles, and endosomes. It cleaves amyloid precursor protein (APP) in the brain into amyloid beta peptide, a major component of the amyloid plaques of Alzheimer's disease (AD), the deposition of which is the central pathology in AD, for which BACE1 is potential therapeutic target.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
He found that Alzheimer's beta-secretase, BACE1, which triggers amyloid pathology, cleaves glycosyltransferases and controls glycan expression.
Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.
Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.
In addition, another drug being developed focuses on beta-secretase (BASE), a compound that makes it possible for beta-amyloid to form.
Also, the companies are collaborating in the development and commercialization of a beta-secretase 1 inhibitor program in AD.
APP's cleavage is done first by beta-secretase, followed by a second cleavage by the gamma-secretase complex.
(35.) Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
An enzyme called beta-secretase (BACE)--which is involved in the formation of beta-amyloid protein, a hallmark of AD--may be responsible for the AD-seizure connection, according to researchers at the MassGeneral Institute for Neurodegenerative Disorders (MGH-MIND).
The product is an oral beta-secretase 1 cleaving enzyme inhibitor.
San Diego, CA, February 19, 2016 --(PR.com)-- Jared Cumming, Director, Global Chemistry at Merck, will give a distinguished speaker presentation on, "Discovery of Verubecestat (MK-8931): A beta-Secretase Inhibitor in Phase 3 Clinical Development for Alzheimer's Disease" at GTCbio's 2nd Protease Inhibitors in Drug Discovery Conference to be held on March 1-2, 2016 in San Diego, CA.