beta-secretase

beta-secretase

(bā-tă-sē-krĕ-tāz),
Agent that exists in two isoforms; protein with homology to the pepsin family of aspartyl proteases involved in the cleavage of beta-amyloid precursor protein; the gene for this protein is located on chromosome 11.

BACE1

B-site amyloid precursor protein (APP) cleaving enzyme. An aspartic-acid protease encoded by BACE1 on chromosome 11q23.2.-q23.3, which is linked to the pathogenesis of Alzheimer's disease and the formation of myelin sheaths in peripheral nerve cells. BACE1 is a transmembrane aspartic protease (beta-secretase) found in the Golgi apparatus, trans-Golgi network, secretory vesicles, and endosomes. It cleaves amyloid precursor protein (APP) in the brain into amyloid beta peptide, a major component of the amyloid plaques of Alzheimer's disease (AD), the deposition of which is the central pathology in AD, for which BACE1 is potential therapeutic target.
References in periodicals archive ?
He found that Alzheimer's beta-secretase, BACE1, which triggers amyloid pathology, cleaves glycosyltransferases and controls glycan expression.
Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.
Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-gamma coactivator 1alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.
In addition, another drug being developed focuses on beta-secretase (BASE), a compound that makes it possible for beta-amyloid to form.
Also, the companies are collaborating in the development and commercialization of a beta-secretase 1 inhibitor program in AD.
APP's cleavage is done first by beta-secretase, followed by a second cleavage by the gamma-secretase complex.
(35.) Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
An enzyme called beta-secretase (BACE)--which is involved in the formation of beta-amyloid protein, a hallmark of AD--may be responsible for the AD-seizure connection, according to researchers at the MassGeneral Institute for Neurodegenerative Disorders (MGH-MIND).
The product is an oral beta-secretase 1 cleaving enzyme inhibitor.
Food and Drug Administration (FDA), the FDA confirmed there was sufficient data to support the advancement of its novel investigational oral beta-secretase cleaving enzyme (BACE) inhibitor E2609 into Phase III clinical studies.
San Diego, CA, February 19, 2016 --(PR.com)-- Jared Cumming, Director, Global Chemistry at Merck, will give a distinguished speaker presentation on, "Discovery of Verubecestat (MK-8931): A beta-Secretase Inhibitor in Phase 3 Clinical Development for Alzheimer's Disease" at GTCbio's 2nd Protease Inhibitors in Drug Discovery Conference to be held on March 1-2, 2016 in San Diego, CA.