beta-lactamase inhibitors

β-lac·tam·ase in·hib·i·tors

drugs (for example, clavulanic acid) that are used to inhibit bacterial β-lactamases; often used with a penicillin or cephalosporin to overcome drug resistance.

be·ta-lac·tam·ase in·hib·i·tors

(bātă lakti-mās in-hibi-tŏrz)
Drugs used to inhibit bacterial β-lactamases; often used with a penicillin or cephalosporin to overcome drug resistance.
References in periodicals archive ?
aeruginosa isolates that were tested for resistance for all five antibiotic classes: cephalosporins, beta-lactam and beta-lactamase inhibitors, carbapenems.
In vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli.
ceftriaxone, cefotaxime, and ceftazidime) by hydrolysis of these antibiotics and which are inhibited by beta-lactamase inhibitors such as clavulanic acid (1).
They are not even inhibited by beta-lactamase inhibitors.
Although the organisms possessing these enzymes are resistant to combinations of beta-lactams and beta-lactamase inhibitors, they remain susceptible to narrow spectrum (Cephalothin) and extended spectrum cephalosporins (Ceftazidime, Ceftriaxone), carbapenems and monobactams (8).
Beta-lactamase inhibitors restore or potentiate the activity of beta-lactam antibiotics.
In our search for beta-lactamase inhibitors from natural resources, we found that the methanol extract of the roots of Fissistigma cavaleriei showed an inhibitory effect on beta-lactamase.
The future development of novel beta-lactams resistant to hydrolysis by these versatile enzymes and the discovery of highly potent "second generation" beta-lactamase inhibitors are eagerly awaited.
They ordered beta-lactamase inhibitors second most commonly, in about 30% of prescriptions.
For upper respiratory tract infections, pediatricians most often prescribed penicillins (in about 42% of prescriptions), followed by macrolides (about 22%) and beta-lactamase inhibitors (16%).
Should a similar resistance phenotype disseminate, it might have strategic implications for the development of new beta-lactamase inhibitors and for selection of beta-lactam compounds to associate wth inhibitors.
Thus, overuse of antibiotics containing beta-lactamase inhibitors will help generate bacteria that are resistant by some other mechanism.

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