beta-lactamase inhibitors

β-lac·tam·ase in·hib·i·tors

drugs (for example, clavulanic acid) that are used to inhibit bacterial β-lactamases; often used with a penicillin or cephalosporin to overcome drug resistance.

be·ta-lac·tam·ase in·hib·i·tors

(bātă lakti-mās in-hibi-tŏrz)
Drugs used to inhibit bacterial β-lactamases; often used with a penicillin or cephalosporin to overcome drug resistance.
References in periodicals archive ?
(3) The class A enzymes contain a serine in the active site and their functions are inhibited by beta-lactamase inhibitors, such as clavulanic acid, tazobactam, and sulbactam.
ARX-1796 is a proprietary oral prodrug of avibactam, the first of a new class of BLI's known as diazabicyclooctanes, or "DBOs," that offer much broader coverage against beta-lactamase enzymes than clavulanic acid or tazobactam, the previously-approved beta-lactamase inhibitors.
Extended-spectrum beta-lactamase-producing organisms were identified based on susceptibility to aztreonam, third and fourth generation cephalosporins (cefpodoxime 8 [micro]g/mL, ceftazidime 8 [micro]g/mL) alone and/or in the presence of beta-lactamase inhibitors (ceftriaxone/clavulanic acid 2 [micro]g/mL, cefotaxime/clavulanic acid 2 [micro]g/mL, ceftazidime/clavulanic acid 2 [micro]g/mL).
aeruginosa isolates that were tested for resistance for all five antibiotic classes: cephalosporins, beta-lactam and beta-lactamase inhibitors, carbapenems.
In vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli.
What types of molecules are beta-lactamase inhibitors?
ceftriaxone, cefotaxime, and ceftazidime) by hydrolysis of these antibiotics and which are inhibited by beta-lactamase inhibitors such as clavulanic acid (1).
They are not even inhibited by beta-lactamase inhibitors. Since the last decade MBL producing isolates have especially appeared in P.
In addition, the previous use of second-generation cephalosporins, macrolides, fluoroquinolones, extended spectrum penicillins, and penicillins with beta-lactamase inhibitors was independently associated with an increased incidence of CDAD (13-15).