(3) The class A enzymes contain a serine in the active site and their functions are inhibited by beta-lactamase inhibitors
, such as clavulanic acid, tazobactam, and sulbactam.
ARX-1796 is a proprietary oral prodrug of avibactam, the first of a new class of BLI's known as diazabicyclooctanes, or "DBOs," that offer much broader coverage against beta-lactamase enzymes than clavulanic acid or tazobactam, the previously-approved beta-lactamase inhibitors
Extended-spectrum beta-lactamase-producing organisms were identified based on susceptibility to aztreonam, third and fourth generation cephalosporins (cefpodoxime 8 [micro]g/mL, ceftazidime 8 [micro]g/mL) alone and/or in the presence of beta-lactamase inhibitors
(ceftriaxone/clavulanic acid 2 [micro]g/mL, cefotaxime/clavulanic acid 2 [micro]g/mL, ceftazidime/clavulanic acid 2 [micro]g/mL).
Beta-lactamases and beta-lactamase inhibitors
. Int J Antimicrob Agents 1999;12 Suppl 1:S3-7; discussion S26-27.
aeruginosa isolates that were tested for resistance for all five antibiotic classes: cephalosporins, beta-lactam and beta-lactamase inhibitors
In vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors
against gram-negative bacilli.
What types of molecules are beta-lactamase inhibitors
ceftriaxone, cefotaxime, and ceftazidime) by hydrolysis of these antibiotics and which are inhibited by beta-lactamase inhibitors
such as clavulanic acid (1).
They are not even inhibited by beta-lactamase inhibitors
. Since the last decade MBL producing isolates have especially appeared in P.
About beta-lactamase inhibitors
and beta-lactam antibiotics
In addition, the previous use of second-generation cephalosporins, macrolides, fluoroquinolones, extended spectrum penicillins, and penicillins with beta-lactamase inhibitors
was independently associated with an increased incidence of CDAD (13-15).