aeruginosa isolates that were tested for resistance for all five antibiotic classes: cephalosporins, beta-lactam and beta-lactamase inhibitors
In vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors
against gram-negative bacilli.
ceftriaxone, cefotaxime, and ceftazidime) by hydrolysis of these antibiotics and which are inhibited by beta-lactamase inhibitors
such as clavulanic acid (1).
They are not even inhibited by beta-lactamase inhibitors
Although the organisms possessing these enzymes are resistant to combinations of beta-lactams and beta-lactamase inhibitors
, they remain susceptible to narrow spectrum (Cephalothin) and extended spectrum cephalosporins (Ceftazidime, Ceftriaxone), carbapenems and monobactams (8).
restore or potentiate the activity of beta-lactam antibiotics.
In our search for beta-lactamase inhibitors
from natural resources, we found that the methanol extract of the roots of Fissistigma cavaleriei showed an inhibitory effect on beta-lactamase.
The future development of novel beta-lactams resistant to hydrolysis by these versatile enzymes and the discovery of highly potent "second generation" beta-lactamase inhibitors
are eagerly awaited.
They ordered beta-lactamase inhibitors
second most commonly, in about 30% of prescriptions.
For upper respiratory tract infections, pediatricians most often prescribed penicillins (in about 42% of prescriptions), followed by macrolides (about 22%) and beta-lactamase inhibitors
Should a similar resistance phenotype disseminate, it might have strategic implications for the development of new beta-lactamase inhibitors
and for selection of beta-lactam compounds to associate wth inhibitors.
Thus, overuse of antibiotics containing beta-lactamase inhibitors
will help generate bacteria that are resistant by some other mechanism.