beta-lactam antibiotics


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Related to beta-lactam antibiotics: beta-lactamase, Aminoglycosides

beta-lactam antibiotics

An important group of drugs that includes the penicillins and the cephalosporins. All have a 4-membered beta-lactam ring as part of the basic structure. Many organisms produce beta-lactamase enzymes that can destroy these antibiotics. This is a common cause of bacterial resistance to antibiotics. Certain molecules called BETA-LACTAM INHIBITORS, however, can bind to beta-lactamase enzymes and inactivate them.

lactam

a cyclic amide formed from aminocarboxylic acids by elimination of water; lactams are isomeric with lactims, which are enol forms of lactams.

β-lactam antibiotics
includes the penicillins, cephalosporins, carbapenems and penems. See also β-lactam ring (below).
β-lactam ring
an integral part of the formula of β-lactam antibiotics. Disruption of the ring by β-lactamase produced by some bacteria, e.g. Escherichia coli, Bacillus anthracis, destroys the antimicrobial activity of the compound.
References in periodicals archive ?
sup][28] conducted a prospective, multicenter study to determine whether the first dose of beta-lactam antibiotics would result in inadequate serum drug concentrations in patients with severe sepsis and septic shock and found that the target pharmacokinetic profiles were achieved in only 75% of patients for meropenem.
Findings of the present study indicates increasing rate of resistance to beta-lactam antibiotics in results of high rate of consumption.
Like all beta-lactam antibiotics it produces its therapeutic effects by crossing the cell wall through porins and binding to penicillin binding proteins (PBP) in the cell membrane.
The properties of OP0595 and its ability to be combined with new or existing beta-lactam antibiotics promise a significant advance in the battle against increasing multi-drug-resistant bacteria.
The Enterome microbiome study, scheduled for completion in the second half of 2014, is expected to provide a better understanding of the harmful effects of beta-lactam antibiotics on the gut bacterial community.
For example, beta-lactam antibiotics frequently lead to IgE-mediated reactions, while pseudo-allergic reactions are frequently related with administration of aspirin, NSAEDs and radiocontrast substances.
In addition, later generations of beta-lactam antibiotics have broader spectrums of activity, which may obviate any benefit offered by adding aminoglycosides.
The acquisition includes Orchid's beta-lactam antibiotics manufacturing complex (comprising Cephalosporin, Penicillin and Carbapenem facilities), pharmaceutical research and development facility at Irungattukottai, Chennai and its generic injectable product portfolio and pipeline.
It is a common structural element of the penicillins, their synthetic and semi-synthetic derivatives, and other related molecules that constitute the broad family of drugs called the beta-lactam antibiotics.
The beta-lactam antibiotics tested are effective for the total elimination of Agrobacterium tumefaciens in indica rice calli (variety J-104), and do not interfere negatively in callus growth and plant regeneration.
6) produced by some bacteria and are responsible for their resistance to beta-lactam antibiotics like penicillins, cephalosporins (are relatively resistant to beta-lactamase), cephamycins, and carbapenems (ertapenem).
The more use of Beta-lactam antibiotics is consistent with the established proof of their effective role in managing infections in the respiratory infections.

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