beta-lactam antibiotics


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Related to beta-lactam antibiotics: beta-lactamase, Aminoglycosides

beta-lactam antibiotics

An important group of drugs that includes the penicillins and the cephalosporins. All have a 4-membered beta-lactam ring as part of the basic structure. Many organisms produce beta-lactamase enzymes that can destroy these antibiotics. This is a common cause of bacterial resistance to antibiotics. Certain molecules called BETA-LACTAM INHIBITORS, however, can bind to beta-lactamase enzymes and inactivate them.
References in periodicals archive ?
This resistance is not only for beta-lactam antibiotics, but also extends to other antibiotic classes through the same plasmid-carrying resistance genes and infection of these bacteria may result in therapeutic failure.2 Beta lactamases cause resistance to beta-lactam agents and are produced by different aerobic gram-negative bacteria (AGNB).3 Hospitals and nursing homes are found as the main reservoirs of ESBLs producing bacteria.
Hahn and colleagues suspect that patients who often don't achieve therapeutic blood levels of antibiotics may be genetically predisposed to metabolize beta-lactam antibiotics quickly.
75%, respectively).[sup][12] Recently, Dulhunty et al .[sup][18] conducted a randomized controlled trial in 25 ICUs to evaluate the efficacy of continuous versus intermittent infusion of beta-lactam antibiotics in patients with severe sepsis and found no difference between treatment groups in clinical cure rates (52.4% vs.
The Cedars-Sinai scientists explain that beta-lactam antibiotics kill normal staph bacteria by inactivating their cell-wall-making enzymes.
(2) ESBLs are plasmid-mediated enzymes (3) and have the ability to hydrolyze diverse types of the newer beta-lactam antibiotics, including extendedspectrum cephalosporins of the 3rd and 4th generation (e.g.
Almost all patients with positive antibodies to streptococci responded to beta-lactam antibiotics (97%).
This is in contrast with the rash observed in patients who received beta-lactam antibiotics, mainly ampicillin or amoxicillin, which is associated with a hypersensitivity reaction to the antibiotic (1) and it is usually pruritic and prolonged.
Austin, TX, August 27, 2015 --(PR.com)-- Bioo Scientific's MaxSignal[R] Beta-Lactam ELISA Test Kit has been validated for the screening of a wide range of beta-lactam antibiotics including ampicillin, penicillin G, amoxicillin, azlocillin, piperacillin, nafcillin, cloxacillin, oxacillin, cefoperazone, ceftiofur and other beta-lactams in a number of food matrices.
For demonstrating Multi-drug resistance of Pseudomonas aeruginosa isolate, the culture was further subjected to antibiotic sensitivity on larger culture plate using more number of antibiotic discs of beta-lactam antibiotics (Penicillins, Amoxicillin, Cloxacilin, Ceftriaxone, Ceftizoxime, Cefuroxime), Aminoglycosides (Streptomycin, Gentamicin, Amikacin), Tetracyclines (Chlortetracycline, Oxytetracycline), Floroquinolones (Norfloxacin, Enrofloxacin), Furazolidine and Chloramphenicol.
Metallo-beta-lactamases are able to hydrolyze virtually all beta-lactam antibiotics including carbapenems.
Analysis of twelve beta-lactam antibiotics in human plasma by HPLC with ultraviolet detection.
Irreversible effects of serum proteins on beta-lactam antibiotics. Antimicrob Agents Chemother 1978;13:628-33.

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