Beta-lactamase inhibitors are administered in combination with beta-lactam antibiotics
to restore or extend their ability to treat bacterial infections caused by beta-lactamase producing, antibiotic-resistant bacteria.
Modern strains of MRSA have become broadly resistant to antibiotics, including beta-lactam antibiotics
, such as penicillins.
(32) Phenotypically, the strains were resistant to the beta-lactam antibiotics
, but much more susceptible to other antibiotic classes than hospital-acquired MRSA (HA-MRSA).
Least-square linear regression analysis was used to assess correlation between antimicrobial use (of beta-lactam antibiotics
and macrolides, expressed in DDD per 1,000 population per day) and the logodds of resistance.
Since all beta-lactam antibiotics
bind to the penicillin-binding proteins, penicillin-resistant strains have diminished susceptibility to other beta-lactam agents.
The acquisition includes Orchid's beta-lactam antibiotics
manufacturing complex (comprising cephalosporin, penicillin and carbapenem facilities) and pharmaceutical R&D facility at Irungattukottai, Chennai, as well as its generic injectable product portfolio and pipeline.
Two major factors responsible for this kind of infection are use of mechanical ventilation and use of beta-lactam antibiotics
. Beta-lactam antibiotics
include Cephalosporins, Penicillins, monobactams and Carbapenems.
Empirical treatment of nosocomial UTIs consists of examination of bacterial spectrum and antibiotics sensitivity testing.1 All over the world, resistance against beta-lactam antibiotics
is increasing due to Extended Spectrum Beta Lactamases (ESBLs) and Amp-c beta-lactamase production.
Hahn and colleagues recruited 20 patients between 1 to 21 years of age who were treated for APEs with beta-lactam antibiotics
at Children's National.
The substrates for these enzymes vary substantially, including Beta-lactam antibiotics
and nucleic acids (both DNA and RNA).
NDM-1 is an enzyme that makes microbes impervious to almost all beta-lactam antibiotics
including carbapenems, which are a backbone for the treatment of antibiotic-resistant bacterial infections.
Summary: New Delhi [India], Dec 17 (NewsVoir): Effective December 10, 2018 Centrient Pharmaceuticals is the new name for DSM Sinochem Pharmaceuticals, the leading manufacturer of beta-lactam antibiotics
and a provider of next-generation statins and anti-fungals.