An enzyme that hydrolyzes β-glucosides in cerebrosides; a deficiency of this enzyme results in Gaucher disease.


an enzyme that catalyzes the hydrolytic cleavage of glucose from glucocerebroside. A deficiency results in accumulation of glucocerebroside in tissues (gaucher's disease). Called also glucosylceramidase, cerebroside β-glucosidase.
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Indeed, life may be tough for individuals who suffer from Gaucher's disease, a rare and inherited disorder wherein the deficiency of enzyme called beta-glucocerebrosidase (that is produced in our cells) results in the accumulation of a fatty substance called glucocerebroside into a sugar and a simpler fat molecule throughout the body, more often in the bone marrow, spleen and liver.
No clinically applicable genotypic or CSF markers exist to support a DLB diagnosis, but there are many promising candidates, including elevated levels of CSF p-tau 181, CSF levels of alpha-and beta-synuclein, (12) and CSF beta-glucocerebrosidase levels.
Gaucher disease is a genetically determined deficiency of the enzyme beta-glucocerebrosidase.