beta-glucocerebrosidase

β-·glu·co·cer·e·bro·sid·ase

(glū'kō-ser'ĕ-brō-sīd'ās),
An enzyme that hydrolyzes β-glucosides in cerebrosides; a deficiency of this enzyme results in Gaucher disease.

β-glucocerebrosidase

an enzyme that catalyzes the hydrolytic cleavage of glucose from glucocerebroside. A deficiency results in accumulation of glucocerebroside in tissues (gaucher's disease). Called also glucosylceramidase, cerebroside β-glucosidase.
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Gaucher disease is an autosomal recessive disorder caused by mutations in the GBA gene which results in a deficiency of the lysosomal enzyme beta-glucocerebrosidase.
Gaucher disease is a genetically determined deficiency of the enzyme beta-glucocerebrosidase.
About Gaucher Disease Gaucher disease is an autosomal recessive disorder caused by mutations in the GBA gene which results in a deficiency of the lysosomal enzyme beta-glucocerebrosidase.
The studies demonstrated that treatment with AT2101 increased the activity of beta-glucocerebrosidase (GCase), prevented accumulation of alpha-synuclein in the brain and improved motor function as assessed in various behavioral tests.
Velaglucerase alfa supplements or replaces beta-glucocerebrosidase, the enzyme
Velaglucerase alfa supplements or replaces beta-glucocerebrosidase, the enzyme that catalyzes the hydrolysis of glucocerebroside, reducing the amount of accumulated glucocerebroside and correcting the pathophysiology of Gaucher disease.
Gaucher disease is caused by a deficiency in the enzyme beta-glucocerebrosidase (GCase) resulting from an inherited genetic mutation.