Abnormal cleavage, or failure to dear beta-amyloid peptides
, causes them to accumulate into oligomers (two to 12 peptide strands joined together), fibrils and plaques.
Two of the identified mutations are responsible for an under-expression of SORL1, resulting in an increase in the production of the beta-amyloid peptide
Protection against beta-amyloid peptide
toxicity in vivo with long-term administration of ferulic acid.
Gamma-secretase cleaves APP at the other end of the beta-amyloid peptide
, releasing it into the space outside the neuron.
It identifies another pathway that's important in regulating levels of beta-amyloid peptide
," reports Dwain Thiele, chief of hepatology.
The Alzheimer's patients had significantly less beta-amyloid peptide
and more tau protein in their spinal fluid than people in the other three groups did, says study coauthor Christoph Hock of the University of Zurich.
In research so far, a synthetic form of the beta-amyloid peptide
, called AN-1792, was injected into six-week-old mice.
Alpha2-macroglobulin associates with beta-amyloid peptide
and prevents fibril formation.
today announced data from a laboratory study demonstrating natural antibodies contained in GAMMAGARD LIQUID [Immune Globulin Intravenous (Human)] (IGIV), marketed as KIOVIG in the European Union, a plasma-derived antibody replacement therapy indicated for primary immunodeficiency disorders and being studied in Alzheimer's disease, binds directly to multiple aggregated, or clustered, forms of the beta-amyloid peptide
In addition, unpublished work by this team suggests that apo E-IV leads to denser deposits of the beta-amyloid peptide
implicated in Alzheimer's disease.
Caprospinol binds to the Beta-Amyloid peptide
, preventing its aggregation into more neurotoxic entities and entry into neurons, as well as protecting neuronal mitochondria from Beta-Amyloid induced damage, and maintaining neuronal cell energy levels.
Like the beta-amyloid peptide
, this 37-amino-acid particle, called amylin, aggregates; but instead of forming plaques in the brain, as beta-amyloid does, amylin accumulates near insulin-producing beta cells located in the pancreas.