ADRB2

(redirected from beta-2 adrenergic receptor)

ADRB2

A gene on chromosome 5q31-q32 that encodes beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB2 binds epinephrine with a 30-fold greater affinity than it does with norepinephrine.
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Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: PLoS One.
Beta-2 adrenergic receptor (ADRB2) gene polymorphisms and the risk of asthma: a meta-analysis of case-control studies.
Recent studies have revealed that beta-2 adrenergic receptor (ADRB2) polymorphism may mediate the bronchodilation response to LABA, thereby influencing the clinical effectiveness of combination treatment [1].
Among around 80 identified polymorphisms in the beta-2 adrenergic receptor gene, ADRB2 Arg16Gly polymorphism is one of the most common nonsynonymous SNPs [1, 11].
Beta-2 adrenergic receptor genetic polymor-phisms and asthma.
Genetic polymorphisms of the beta-2 adrenergic receptor in Israelis with severe asthma compared to non-asthmatic Israelis.
Beta-blockers should be added after a few days and in the presence of an effective alpha-adrenergic blockade since they can worsen the BP profile by inhibiting vasodilatation mediated by beta-2 adrenergic receptors and thus increasing vasoconstriction [16].
Maternal side effects associated with beta-adrenergic agonists are thought to arise from stimulation of the beta-1 and beta-2 adrenergic receptors. Stimulation of the former increases maternal heart rate and stroke volume, whereas stimulation of the beta-2 adrenergic receptors causes the relaxation of smooth muscle, including the muscles of the myometrium, blood vessels, and bronchial tree.
Histologically, beta-2 adrenergic receptors are located primarily within bronchiole smooth muscle; beta-1 adrenergic receptors are located within the cardiovascular system.