ADRB1

(redirected from beta-1 adrenergic receptor)

ADRB1

A gene on chromosome 10q24-q26 that encodes beta-1-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB1 binds epinephrine and norepinephrine with the same affinity.
References in periodicals archive ?
The investment was triggered by the excellent progress made both by HTL's in-house team and by its founding scientists at the MRC Laboratory of Molecular Biology, Cambridge, who have recently solved the structure of the beta-1 adrenergic receptor based on their novel GPCR-stabilisation methodology.
The Bristow/Aleong editorial comments that the data from BEST appear to be different from the data for the drugs evaluated in the Rienstra study, because retrospective analyses of the data from BEST appear to show evidence of efficacy for Gencaro in HFREF patients with AF, and enhanced efficacy for those HFREF patients with AF who possess a common genetic variant in the cardiac beta-1 adrenergic receptor (AR), the primary drug target of beta-blockers for cardiovascular indications.
As previously reported at the American Heart Association's Scientific Sessions 2011, Gencaro reduced the risk of developing AF by 74% in the genetic subgroup that was homozygous for the 389 arginine version of the beta-1 adrenergic receptor, which has high affinity for norepinephrine.
Patent and Trademark Office (USPTO) has issued a patent on methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient has a specific genotype - homozygous for the arginine 389 polymorphism in the beta-1 adrenergic receptor.
In this study, Gencaro appeared to produce enhanced clinical outcomes in the 47% of patients who were homozygous for the amino acid position 389 arginine polymorphism of the beta-1 adrenergic receptor, a variant with higher functional activity and higher affinity for norepinephrine, which the Company believes is the most favorable genotype for a positive response to Gencaro.
These patients are homozygous arginine at the amino acid position 389 beta-1 adrenergic receptor polymorphism.
Results from the GRAHF study on two gene variations in aldosterone synthase and beta-1 adrenergic receptor were presented in Atlanta at the 55th Annual Scientific Session of the American College of Cardiology.
The beta-1 adrenergic receptor is involved in the regulation of cardiac rhythm and fluency.
Histologically, beta-2 adrenergic receptors are located primarily within bronchiole smooth muscle; beta-1 adrenergic receptors are located within the cardiovascular system.