Type 1 diabetes is an autoimmune metabolic condition in which the body kills off all the pancreatic beta cells
that produce the insulin needed for glucose regulation in the body.
21 Beta cell
diameter was determined by measuring the average of 5 inter-nuclear distances, including one nucleus, in five randomly selected islets per section.
Human and rat beta cells
differ in glucose transporter but not in glucokinase gene expression.
Results: Significant differences were observed between obese and non-obese individuals regarding insulin resistance, beta cell
function, and BMI and serum total cholesterol.
In humans, pancreatic acinar cells can serve as progenitor for pancreatic islets; a concept with substantial implications for therapeutic efforts to increase insulin producing beta cell
mass in diabetic patients (Gao et al.
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
The work, funded by the Health Research Board and the Mater Foundation, also showed that even in type 1 diabetics, the body continues to try and produce beta cells
Type 1 diabetes is an autoimmune condition which destroys the beta cells
and leaves patients dependent on insulin injections.
It is not known at this stage if the bone marrow stem cells are replacing the faulty immune system cells with ones that do not destroy the beta cells
, or if the bone marrow cells are able to support the production of new beta cells
Symptoms of IDDM usually develop over a short period, although beta cell
destruction can begin months, even years, earlier.
Emerging diabetes drugs consider beta cell
mass and function as an important target
Using known methods, the scientists analyzed about 600 different cells on their path to beta cell
differentiation and individually examined the cells to find out how much they molecularly resemble the beta cells