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Berylliosis is lung inflammation caused by inhaling dust or fumes that contain the metallic element beryllium. Found in rocks, coal, soil, and volcanic dust, beryllium is used in the aerospace industry and in many types of manufacturing. Berylliosis occurs in both acute and chronic forms. In some cases, appearance of the disease may be delayed as much as 20 years after exposure to beryllium.


In the 1930s, scientists discovered that beryllium could make fluorescent light bulbs last longer. During the following decade, the hard, grayish metal was identified as the cause of a potentially debilitating, sometimes deadly disease characterized by shortness of breath and inflammation, swelling, and scarring of the lungs.
The manufacture of fluorescent light bulbs is no longer a source of beryllium exposure, but serious health hazards are associated with any work environment or process in which beryllium fumes or particles become airborne. Working with pure beryllium, beryllium compounds (e.g. beryllium oxide), or beryllium alloys causes occupational exposure. So do jobs involving:
  • electronics
  • fiber optics
  • manufacturing ceramics, bicycle frames, golf clubs, mirrors, and microwave ovens
  • mining
  • nuclear weapons and reactors
  • reclaiming scrap metal
  • space and atomic engineering
  • dental and laboratory technology
Beryllium dust and fumes are classified as toxic air pollutants by the Environmental Protection Agency (EPA). It is estimated that 2-6% of workers exposed to these contaminants eventually develop berylliosis.

Causes and symptoms

Coughing, shortness of breath, and weight loss that begin abruptly can be a symptom of acute berylliosis. This condition is caused by beryllium air pollution that inflames the lungs making them rigid; it can affect the eyes and skin as well. People who have acute berylliosis are usually very ill. Most recover, but some die of the disease.

Key terms

Beryllium — A steel-grey, metallic mineral used in the aerospace and nuclear industries and in a variety of manufacturing processes.
Chelation therapy — A treatment using chelating agents, compounds that surround and bind to target substances allowing them to be excreted from the body.
Corticosteroids — A group of anti-inflammatory drugs.
Chronic berylliosis is an allergic reaction to long-term exposure to even low levels of beryllium dust or fumes. A systemic disease that causes formation of abnormal lung tissue and enlargement of the lymph nodes, chronic berylliosis also may affect other parts of the body. The symptoms of chronic berylliosis are largely the same as those seen in acute berylliosis, but they develop more slowly.


Berylliosis is initially suspected if a patient with symptoms of the disease has a history of beryllium exposure. A chest x ray shows characteristic changes in the lungs. However, since these changes can resemble those caused by other lung diseases, further testing may be necessary.
The beryllium lymphocyte proliferation test (BeLPT), a blood test that can detect beryllium sensitivity (i.e. an allergic reaction to beryllium), is used to screen individuals at risk of developing berylliosis. When screening results reveal a high level of sensitivity, BeLPT is performed on cells washed from the lungs. This test is now considered the most definitive diagnostic test for berylliosis.


Individuals with beryllium sensitivity or early-stage berylliosis should be transferred from tasks that involve beryllium exposure and regularly examined to determine whether the disease has progressed.
Acute berylliosis is a serious disease that occasionally may be fatal. Ventilators can help patients with acute berylliosis breathe. Prompt corticosteroid therapy is required to lessen lung inflammation.
Chronic beryllium disease is incurable. Corticosteroid therapy is often prescribed, but it is not certain that steroids can alter the progression of the disease, and they have no effect on scarring of lung tissue. Cleansing the lungs of beryllium is a slow process, so long-term therapy may be required. Chelation therapy is currently under investigation as a treatment for the disease.


Most patients with acute berylliosis recover fully 7-10 days after treatment begins, and the disease usually causes no after effects.
Patients whose lungs are severely damaged by chronic berylliosis may experience fatal heart failure because of the strain placed on the heart.


Eliminating exposure to beryllium is the surest way to prevent berylliosis. Screening workers who are exposed to beryllium fumes or dust or who develop an allergic reaction to these substances is an effective way to control symptoms and prevent disease progression.



American Lung Association. 1740 Broadway, New York, NY 10019. (800) 586-4872.
Beryllium Support Group. P.O. Box 2021, Broomfield, CO 80038-2021. (303) 412-7065. 〈∼mhj〉.
Environmental Health Center. 1025 Connecticut Ave., NW, Washington, DC 20036. (202) 293-2270.


beryllium poisoning, usually involving the lungs and less often the skin, subcutaneous tissues, lymph nodes, liver, and other structures. The fumes, oxide, salts, and finely divided dust of beryllium all may cause a tissue reaction when inhaled or implanted in the skin. Acute berylliosis is basically a toxic or allergic pneumonitis, sometimes with rhinitis, pharyngitis, and tracheobronchitis. Chronic berylliosis, which is more common, is characterized by development of granulomas and a diffuse interstitial inflammatory reaction with clinical and pathological findings often indistinguishable from those of sarcoidosis.


Beryllium poisoning characterized by acute pneumonia or chronic interstitial granulomatous fibrosis, especially of the lungs, from inhalation of beryllium.


A chronic lung disease caused by inhalation of beryllium dusts, salts or fumes, regarded by some as a delayed hypersensitivity reaction, in which beryllium acts as an MHC II-restricted antigen.

Acute berylliosis 
Causes chemical acute pneumonitis, ­caused by short exposures to high concentrations of beryllium due to lung toxicity.
Chronic berylliosis 
Causes chronic interstitial, sarcoid-like granulomatous lung disease due to beryllium levels over periods from months to years.


Beryllium poisoning characterized by granulomatous fibrosis of the lungs from chronic inhalation of beryllium.


Disease caused by contact with the poisonous metal element beryllium found in fluorescent light tubes and TV tubes. It is a persistent form of pneumonia caused by inhaling dust or fumes containing the metal. Severe lung damage may result.
References in periodicals archive ?
After a 1943 outbreak of berylliosis among workers and neighbors of a beryllium plant in Lorain, Ohio threatened precisely the public relations fiasco that the AEC feared, it took steps to reduce exposures to beryllium at beryllium processing and weapons manufacturing plants throughout the country.
(33) OSHA based the proposal on its determinations that at least a dozen workers per year were being diagnosed with berylliosis and that beryllium had been shown to cause cancer in laboratory animals.
But this is just the "tip of the iceberg" according to the doctor, who claims there are also a further 70 cases of berylliosis near the tip.
This is perhaps of even greater concern because berylliosis should not occur at all within the population apart from in cases where people working in factories come into contact with the toxic metallic substance beryllium.
Interaction of genetic and exposure factors in the prevalence of berylliosis. Am J Ind Med 32:337-340.
(48-50) Some claim that Schaumann bodies are nearly as common in berylliosis as in sarcoidosis.
Bronchoalveolar lavage in a patient with chronic berylliosis: evidence for hypersensitivity pneumonitis.
The influence of cutaneous hyper-sensitivity to beryllium on the development of experimental pulmonary berylliosis. Trans NY Acad Sci 36:78-93.
(59) Moreover, berylliosis can produce histopathologic changes identical to those of sarcoidosis, 60 so it is appropriate to include berylliosis in the differential diagnosis of sarcoidosis.
Diffuse Diseases Associated With Nodular Granulomatous Inflammation Sarcoidosis Granulomatous infections Intravenous talcosis Pneumoconioses (eg, inhalation talcosis, berylliosis) Aspiration pneumonia Wegener granulomatosis Table 7.
Immunogenetic basis of environmental lung disease: lessons from the berylliosis model.
Key words: berylliosis, beryllium, lung neoplasms, occupational diseases, smoking.