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thiamin deficiencyA vitamin deficiency characterised by malnutrition, softened bones and mental depression, due to an absence of dietary thiamin. The clinical disease, beri-beri, is divided into a “wet” form, which causes congestive heart failure, and a “dry” form, which causes neurologic disease in the form of peripheral neuropathy and Wernicke-Korsakoff syndrome.
beri-beriNutrition A disease caused by deficiency of thiamine–vitamin B1, which affects the heart–cardiac dilatation, fatty degeneration, peripheral nerves—myelinolysis and axonal degeneration, subcutaneous tissues–edema and vascular congestion and serosal linings–effusions Clinical Fatigue, apathy, irritability, depression, muscular atrophy, paresthesias, abdominal pain and if extreme, ↑ intracranial pressure and coma. See Shoshin beri-beri.
- Dry beri-beri
- Affects central and peripheral nervous systems Clinical, childrenPlethoric with pallor, hoarseness due to nerve paralysis, apathy, dyspnea, tachycardia, hepatomegaly
- Wet beri-beri
- More cardiocentric Clinical The afflicted children are malnourished with pallor, edema, tachycardia, dyspnea, renal failure, right-sided cardiac failure Treatment Thiamine-rich foods, eg milk, vegetables, cereals, fruits