contains a mixture of phospholipids, neutral lipids, fatty acids, and surfactant-associated proteins such as SP-B and SP-C.
The baby received exogenous surfactant (beractant
100 mg/kg) and was ventilated on synchronized intermittent mandatory ventilation mode.
Surfactant (Survanta,(R) Abbott Laboratory, Chicago, IL) used in the study was given by intratracheal route, 100mg of beractant
phospholipids/kg birth weight/dose (4mL/kg/dose), as per manufacturer's instructions and standard protocol.
With this, the DOH has been taking advantage of the funds to purchase beractant
and surfactanta treatment for respiratory distress syndrome (RDS) acquired by pretermsfor 2014 and 2015.
(23) in which proctant alpha was given to one group of patients with RDS and beractant
was given to another group, it was found that the requirement for a second dose of surfactant was lower, extubation occured earlier, oxygen requirement was lower, but the rate of BPD was higher in the proctant alfa (Curosurf[C]) group compared to the beractant
(Survanta[C]) group and the morbidity and mortality rates were similar in both groups.
In the study, the infants were treated with lucinactant (Surfaxin), colfosceril palmitate (Exosurf), or beractant
(Survanta) within 30 minutes of birth.
The independent analysis, which was published in the eFirst Pages section of the Pediatrics website, was aimed at comparing the efficacy of CUROSURF versus Survanta (beractant
) and Infasurf (calfactant) with respect to clinical outcomes among preterm infants with RDS.
Baroutis y colaboradores (12) compararon el regimen con tres surfactantes naturales: alveofact, poractant y beractantes
, en recien nacidos prematuros con SDR, y llegaron a la conclusion de que los dos primeros tipos de surfactante generaron menos dias de ventilacion, menos dias de suministro de oxigeno y menor estancia hospitalaria comparados con el grupo de beractant
) is derived from minced bovine lung extracts with DPPC added to the preparation.
The results concluded that KL-4 surfactant reduced inflammation and cell injury, resulting in improved cell survival and function compared with both a saline control as well as beractant
(Survanta(r)), an animal-derived surfactant and currently the most frequently prescribed surfactant in the United States.
Four large (several hundred in each group), prospective randomized clinical trials comparing Exosurf (synthetic, no apoproteins) to Survanta (beractant
) and to Infasurf (calfactant) have been conducted.