Examples of CCBs include bepridil
(Vasocor[R]), amiodipine besylate (Norvasc[R]), and verapamil hydrochloride (Calan SR[R]).
Evaluation of drug-induced QT interval modifications in dynamic electrocardiography: the case of bepridil
Common drug-drug interactions with ART  Class of drug Concomitant medication PIs Anticoagulant: warfarin Anticonvulsants: carbamazepine, phenobarbital, phenytoin Antifungals: ketoconazole, itraconazole, voriconazole Calcium channel blockers: diltiazem, nifedipine, verapamil, amlodipine, nicardipine, isradipine, felodipine, bepridil
HMG-CoA reductase inhibitors (statins): lovastatin, simvastatin, atorvastatin Immunosuppressive drugs: cyclosporine, tacrolimus, sirolimus Opioids: methadone PD[E.
AFib is often initially treated with antiarrhythmic drugs, such as amiodarone (Cordarone, Pacerone), bepridil
hydrochloride (Vascor), or disopyramide (Norpace).
, clinidipine, clevidipine, diltazem, fendilinem,
Effects of two Ca-entry blockers bepridil
and nitredipine on isolated vessels.
tetralols (such as bepridil
, which is no longer sold in the US).
On January 31 the FDA announced that the Sustiva (efavirenz) package insert had been changed "to include drug-drug interaction information regarding coadministration of efavirenz with rifampin, diltiazem, itraconazole, voriconazole, atorvastatin, pravastatin, simvastatin, pimozide and bepridil
7) When cases of TdP were analyzed by individual medication, the observed prevalence in women was greater than that in men for quinidine, disopyramide, amiodarone, sotalol, bepridil
, and prenylamine (P < .
The following drugs should not be combined with ritonavir: bepridil
(Vascor), amiodarone (Cordarone), flecainide (Tambocor), propafenone (Rythmol), quinidine (Quinidex), simvastatin (Zocor), lovastatin (Mevacor), cisapride (Propulsid), clozapine (Clozaril), midazolam (Versed), triazolam (Halcion), dihydroergotamine (DHE 45) and ergotamine (Cafergot).
All but 2 of these 13 criteria (use of bepridil
or phenylbutazone as first-line therapy) reference drug-drug interactions, and all can produce severe consequences.
Drug Category Potential Alternatives Analgesic (pain reliever): meperidine (Demerol) acetaminophen (Tylenol, others) piroxicam (Feldene) aspirin (Bayer, others) propoxyphene (Darvon, others) oxycodone (Percocet, others) Cardiovascular (for the heart): amiodarone (Cordarone) flecainide (Tambocor) very limited clinical propafenone (Rythmol) experience quinidine (various) Antimycobacterial (Anti-TB or anti-MAC): clarithromycin (Biaxin) azithromycin (Zithromax) rifabutin (Mycobutin) ethambutol (Myambutol) Calcium Channel Blocker (for the heart): bepridil
(Vascor) very limited clinical experience Ergot Alkaloid (vasoconstrictor): dihydroergotamine (D.