(be-poe-tass-teen) ,


(trade name)


Therapeutic: ocular agents
Pharmacologic: antihistamines
Pregnancy Category: C


Treatment of itching associated with allergic conjunctivitis.


Acts as a histamine H1 receptor antagonist; also inhibits the release of histamine from mast cells; does not bind to or inactivate histamine.

Therapeutic effects

Decreased ocular itching associated with allergic conjunctivitis.


Absorption: Some systemic absorption follows ophthalmic administration.
Distribution: Unknown.
Metabolism and Excretion: Minimally metabolized by the liver; 75–90% excreted unchanged in urine.
Half-life: Uknown.

Time/action profile (antihistaminic activity)

ophthwithin 15 min1–2 hr†12 hr
†blood levels


Contraindicated in: Hypersensitivity.
Use Cautiously in: Contact lens use ; Obstetric: Use during pregnancy potential maternal benefit justifies the potential risk to fetus; Lactation: Use cautiously during breastfeeding; Pediatric: Safe and effective use in children <2 yr has not been established.

Adverse Reactions/Side Effects

Central nervous system

  • headache

Ear, Eye, Nose, Throat

  • nasopharyngitis


  • taste in mouth following instillation (most frequent)


Drug-Drug interaction

None noted.


Ophthalmic (Adults) One drop in affected eye(s) twice daily.


Ophthalmic solution: 1.5%

Nursing implications

Nursing assessment

  • Assess signs and symptoms of allergic conjunctivitis (redness, itching, watering) periodically during therapy.

Potential Nursing Diagnoses

Deficient knowledge, related to medication regimen (Patient/Family Teaching)


  • Ophthalmic: Instill 1 drop into affected eyes twice daily. See for administration guidelines.

Patient/Family Teaching

  • Instruct patient to instill bepotastine drops as directed. Do not touch dropper to eye or to any surface.
  • Advise patient to remove contact lens prior to instillation. Do not use bepotastine for treatment of irritation related to contact lens. Do not wear contact lens if eyes are red. Contact lens may be reinserted 10 min following instillation.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

  • Decrease in ocular itching due to allergic conjunctivitis.
References in periodicals archive ?
There are no human eye data for bepotastine (Bepreve), ketotifen (Alaway), and olopatadine (Pataday, Patanol).
5 January 2012 - ISTA Pharmaceuticals Inc (NASDAQ:ISTA) said on Wednesday that it has launched its Phase II clinical trial of BEPOSONE, a nasal spray combining bepotastine besilate with a steroid for the treatment of symptoms related to seasonal allergic rhinitis.
ISTA plans to enrol some 600 patients in Texas who will be administered either the bepotastine besilate-steroid combination nasal spray, nasal spray containing only one of the active agents, or placebo nasal spray for two weeks.
Bepotastine (Bepreve; C), an antihistamine, and besifloxacin (Besivance; C), a quinolone antibiotic, are new ophthalmic products.
Bepotastine, besifloxacin, ecallantide, golimumab, ofatumumab, prasugrel, telavancin, and vigabatrin appear to be compatible with breastfeeding, but there are human data only for vigabatrin.
M2 PHARMA-October 6, 2010-ISTA reports encouraging preliminary Phase I/II results for bepotastine besilate nasal spray(C)2010 M2 COMMUNICATIONS
6 October 2010 - US ISTA Pharmaceuticals Inc (NASDAQ: ISTA) reported on Wednesday positive preliminary results from a Canadian Phase I/II study of bepotastine besilate nasal spray for the treatment of symptoms associated with seasonal allergic rhinitis.
The findings demonstrated two of the three bepotastine besilate concentrations tested were effective in relieving patients' nasal symptoms after exposure to seasonal allergens.