bepotastine
bepotastine
(be-poe-tass-teen) ,Bepreve
(trade name)Classification
Therapeutic: ocular agentsPharmacologic: antihistamines
Indications
Treatment of itching associated with allergic conjunctivitis.
Action
Acts as a histamine H1 receptor antagonist; also inhibits the release of histamine from mast cells; does not bind to or inactivate histamine.
Therapeutic effects
Decreased ocular itching associated with allergic conjunctivitis.
Pharmacokinetics
Absorption: Some systemic absorption follows ophthalmic administration.
Distribution: Unknown.
Metabolism and Excretion: Minimally metabolized by the liver; 75–90% excreted unchanged in urine.
Half-life: Uknown.
Time/action profile (antihistaminic activity)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
ophth | within 15 min | 1–2 hr† | 12 hr |
Contraindications/Precautions
Contraindicated in: Hypersensitivity.
Use Cautiously in: Contact lens use ; Obstetric: Use during pregnancy potential maternal benefit justifies the potential risk to fetus; Lactation: Use cautiously during breastfeeding; Pediatric: Safe and effective use in children <2 yr has not been established.
Adverse Reactions/Side Effects
Central nervous system
- headache
Ear, Eye, Nose, Throat
- nasopharyngitis
Gastrointestinal
- taste in mouth following instillation (most frequent)
Interactions
Drug-Drug interaction
None noted.Route/Dosage
Ophthalmic (Adults) One drop in affected eye(s) twice daily.
Availability
Ophthalmic solution: 1.5%
Nursing implications
Nursing assessment
- Assess signs and symptoms of allergic conjunctivitis (redness, itching, watering) periodically during therapy.
Potential Nursing Diagnoses
Deficient knowledge, related to medication regimen (Patient/Family Teaching)Implementation
- Ophthalmic: Instill 1 drop into affected eyes twice daily. See for administration guidelines.
Patient/Family Teaching
- Instruct patient to instill bepotastine drops as directed. Do not touch dropper to eye or to any surface.
- Advise patient to remove contact lens prior to instillation. Do not use bepotastine for treatment of irritation related to contact lens. Do not wear contact lens if eyes are red. Contact lens may be reinserted 10 min following instillation.
- Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Evaluation/Desired Outcomes
- Decrease in ocular itching due to allergic conjunctivitis.
Drug Guide, © 2015 Farlex and Partners