However, the
benzodiazepine receptor agonists such as zaleplon, Zolpidem, and eszopiclone, while lacking evidence in the pediatric population, may be worthwhile considerations as their varying half-lives allow for specificity in treating sleep-onset vs.
Patients met Beers CNS polypharmacy criteria if three or more of the following medications were initiated or continued: antipsychotics, benzodiazepines, nonbenzodiazepine
benzodiazepine receptor agonists, tricyclic antidepressants, selective serotonin reuptake inhibitors, and opioids.
Charney, "Decreased
benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder," American Journal of Psychiatry, vol.
Vomero et al., "Molecular basis of peripheral vs central
benzodiazepine receptor selectivity in a new class of peripheral
benzodiazepine receptor ligands related to alpidem," Journal of Medicinal Chemistry, vol.
Guilarte et al., "Translocator protein (18 kDa): new nomenclature for the peripheral-type
benzodiazepine receptor based on its structure and molecular function," Trends in Pharmacological Sciences, vol.
Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II
benzodiazepine receptor pharmacology.
All FDA-approved
benzodiazepine receptor agonists work on GABAA receptors; therefore, the difference among them is half-life.
Of special interest is Rozerem is not expected to exhibit rebound insomnia, memory impairment, respiratory depression, drug abuse, dependence, and withdrawal as by some of the
benzodiazepine receptor agonists.
Therefore, we used a classic benzodiazepine drug association protocol and a [GABA.sub.A]
benzodiazepine receptor site antagonist, flumazenil, for CNS depression reversal.
Overview-flavonoids: a new family of
benzodiazepine receptor ligands.
The 18 kDa translocator protein [1] (TSPO; previously-known as the peripheral
benzodiazepine receptor, PBR) has been extensively studied for its intricate biological functions.
angustifolia has been found to contain flavonoid components and some flavones, such as chrysin, (5, 7-dihydroxyflavone) which have a partial agonistic effect on
benzodiazepine receptors. Central
benzodiazepine receptor (BDZ-R) agonists have been known to induce multiple effects including anxiolytic, myorelaxant, anticovulsant, hypnotic and amnestic effects (44-46).