However, the benzodiazepine receptor
agonists such as zaleplon, Zolpidem, and eszopiclone, while lacking evidence in the pediatric population, may be worthwhile considerations as their varying half-lives allow for specificity in treating sleep-onset vs.
Patients met Beers CNS polypharmacy criteria if three or more of the following medications were initiated or continued: antipsychotics, benzodiazepines, nonbenzodiazepine benzodiazepine receptor
agonists, tricyclic antidepressants, selective serotonin reuptake inhibitors, and opioids.
Charney, "Decreased benzodiazepine receptor
binding in prefrontal cortex in combat-related posttraumatic stress disorder," American Journal of Psychiatry, vol.
Vomero et al., "Molecular basis of peripheral vs central benzodiazepine receptor
selectivity in a new class of peripheral benzodiazepine receptor
ligands related to alpidem," Journal of Medicinal Chemistry, vol.
Guilarte et al., "Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor
based on its structure and molecular function," Trends in Pharmacological Sciences, vol.
Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor
All FDA-approved benzodiazepine receptor
agonists work on GABAA receptors; therefore, the difference among them is half-life.
Of special interest is Rozerem is not expected to exhibit rebound insomnia, memory impairment, respiratory depression, drug abuse, dependence, and withdrawal as by some of the benzodiazepine receptor
Therefore, we used a classic benzodiazepine drug association protocol and a [GABA.sub.A] benzodiazepine receptor
site antagonist, flumazenil, for CNS depression reversal.
Overview-flavonoids: a new family of benzodiazepine receptor
The 18 kDa translocator protein  (TSPO; previously-known as the peripheral benzodiazepine receptor
, PBR) has been extensively studied for its intricate biological functions.
angustifolia has been found to contain flavonoid components and some flavones, such as chrysin, (5, 7-dihydroxyflavone) which have a partial agonistic effect on benzodiazepine receptors
. Central benzodiazepine receptor
(BDZ-R) agonists have been known to induce multiple effects including anxiolytic, myorelaxant, anticovulsant, hypnotic and amnestic effects (44-46).