benzodiazepine derivative

benzodiazepine derivative

[ben′zōdī·az′əpin]
one of a group of psychotropic agents, including the tranquilizers chlordiazepoxide, diazepam, oxazepam, lorazepam, and chlorazepate, prescribed to alleviate anxiety, and the hypnotics flurazepam and triazolam, prescribed in the treatment of insomnia. Tolerance and physical dependence occur with prolonged high dosage. Withdrawal symptoms, including seizures, may follow abrupt discontinuation. Adverse reactions to the benzodiazepines include drowsiness, ataxia, and a paradoxic increase in aggression and hostility. These reactions are not common with the usual recommended dosage.
References in periodicals archive ?
Nishiyama reports that midazolam, which is itself a water soluble benzodiazepine derivative by virtue of being a benzodiazepine-GABAA receptor complex agonist, exhibits synergistic analgesia for thermally-induced acute nociception as well as persistent inflammatory nociceptive activation both with N-Methyl-DAspartica Acid (NMDA) and 2-amino-3-(5- methyl-3-oxo-12-oxazol-4-yl) Propanoic Acid (AMPA) receptor antagonists.
Adjunctive therapy with the benzodiazepine derivative clobazam significantly reduced the occurrence of drop seizures in the largest clinical trial to date in patients with Lennox-Gastaut syndrome.
Apigenin, one of the predominant flavonoids in chamomile, was found to competitively inhibit the binding of flunitrazepam, a benzodiazepine derivative, and was fitted into a pharmacophore model for ligands binding to the GABAA receptor benzodiazepine site.
Diazepam, first marketed as Vali-um is a benzodiazepine derivative drug, used as a highly effective tranquilliser and sedative, It is commonly used for treating anxiety, stress, tension insomnia, seizures, alcohol withdrawal, muscle spasms tension and anxiety and in some surgical procedures to induce amnesia.
Since the benzodiazepine derivative flunitrazepam (eg, in Rohypnol) has been used as a tool to incapacitate potential victims of, for example, robbery or rape, the pharmaceutical company Hoffmann La Roche mixes the Rohypnol tablets with the coloring agent indigo carmine to prevent its hidden admixture in beverages.