benznidazole


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benznidazole

An antiprotozoal drug used mainly to treat South American trypanosomiasis (Chagas' disease). The drug is on the WHO official list.
References in periodicals archive ?
Another antiparasitic drug, benznidazole, was approved to treat children aged 2-12 years with Chagas disease in 2017, Dr.
All patients with a diagnosis of acute Chagas disease were prescribed benznidazole for 60 days (5).
The two drugs used for treating Chagas disease are benznidazole and nifurtimox (1,2), which have been used in Latin America since the 1970s and 1960s, respectively.
The use of only one 2017 novel drug (Benznidazole) during breastfeeding has been reported.
Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions.
Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effective during the chronic phase.
Case Report Uneventful benznidazole treatment of acute Chagas disease during pregnancy : a case report.
Valencia-Hernandez et al., "Risk factors for treatment interruption and severe adverse effects to benznidazole in adult patients with Chagas disease," PLoS ONE, vol.
Cunha-Filho, "Simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: a tool for quality control in the development of formulations," Spectrochimica Acta, Part A Molecular and Biomolecular Spectroscopy, vol.
Graminha et al., "Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole," Journal of Inorganic Biochemistry, vol.
Subjects with any of the following conditions were excluded from the study: previous treatment with benznidazole, coinfectious diseases, pregnancy, autoimmune diseases, cancer, and associated cardiovascular diseases that hampered the classification of the cardiac form of Chagas disease or the associated digestive form of Chagas disease.
Prominent myocardial lesions with intense inflammatory process, evolution in parasitemia with peak between 21 and 25 days of postinfection, distinct myotropism with involvement of the skeletal musculature resulting in extensive lesions in the skeletal muscle fibers, electrocardiographic alterations, and resistance to chemotherapeutics such as benznidazole and nifurtimox are characteristics of this strain.