benzimidazole


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benz·im·id·a·zole

(benz-im-id-ā'zōl),
1. A ring system composed of a benzene ring fused with an imidazole ring; occurs in nature as part of the vitamin B12 molecule.
2. A class of antihelmintic, often used to treat nematodes and cestodes.

benzimidazole

(bĕn′zə-mĭ-dăz′ōl′, -mĭd′ə-zōl′)
n.
1. A heterocyclic compound, C7H6N2, that is used in organic synthesis and inhibits the growth of certain fungi.
2. Any of various derivatives of this compound, such as thiabendazole, used especially as anthelmintic and antifungal agents.

benzimidazole

A family of broad-spectrum antiparasitics (abendazole, mebendazole, thiabendazole) active against nematodes (roundworms, ascariasis, enterobius, hookworm infection, strongyloidiasis, trichuriasis), cestodes (flatworms, cysticercosis, echinococcosis) and protozoa (giardiasis, microsporidiosis); benzimidazole acts by binding free beta-tubulin, inhibiting its polymerisation and the microtubule-dependent uptake of glucose.
 
Adverse effects
Abdominal pain, nausea, vomiting, alopecia, increased aminotransferases, neutropenia.

benzimidazole

a group of compounds with anthelmintic properties. They all have the same central chemical structure—1,2-diaminobenzene. Some of the better known pharmaceutical compounds are thiabendazole, albendazole, cambendazole, fenbendazole, mebendazole, oxfendazole, oxibendazole and parbendazole.
References in periodicals archive ?
1989) Genetic and molecular analysis of a Caenorhabditis elegans O-tubulin that conveys benzimidazole sensitivity.
Antifungal activity of organic and organometallic derivatives of benzimidazole and benzothiazole.
A single peak is observed at 2[theta] = 27[degrees], which corresponds to parallel benzimidazole ring forming a stacked structure of ABPBI [13, 14].
Seven benzimidazole pesticides combined at sub-threshold levels induce micronuclei in vitro.
Belomoina, "High temperature proton exchange membranes based on poly(arylene ether)s with benzimidazole side groups for fuel cells," Journal of Materials Chemistry, vol.
Resistance to two wormers was considered to be low but of the other two, 78% were resistant to Benzimidazole and 34% were resistant to Levamisole.
It looked at 47 Welsh farms and the effectiveness of four types of wormer: Benzimidazole (1-BZ); Levamisole (2-LV); Ivermectin (3-ML) and Moxidectin (3-ML).
A 3-day course of benzimidazole is the anthelminthic drug of choice.
One of the solutions contains a precise ratio of amino phenyl benzimidazole and paraphenylene diamine dihydrochloride.
The egg hatch test was initially developed for the diagnosis of benzimidazole resistance helminths.
Dioxybenzone(X) Phenyl benzimidazole Homosalate# sulfonic acid (WS)# Meradimate (A)# Sulisobenzone(X) Ecamsule *(1) (A)(WS)# Titanium dioxide (A) Octocrylene# Trolamine salicylate(X)(WS) Octinoxate# Zinc oxide (A)# * 1-Approved in L'Oreal formulations only.
Wang, X, Yang, H, Cao, P, Zhang, Z, "Study of the Adsorption of Benzimidazole and 2-Mercaptobenzothiazole on an Iron Surface by Confocal Micro-Raman Spectroscopy.