benzimidazole


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benz·im·id·a·zole

(benz-im-id-ā'zōl),
1. A ring system composed of a benzene ring fused with an imidazole ring; occurs in nature as part of the vitamin B12 molecule.
2. A class of antihelmintic, often used to treat nematodes and cestodes.

benzimidazole

(bĕn′zə-mĭ-dăz′ōl′, -mĭd′ə-zōl′)
n.
1. A heterocyclic compound, C7H6N2, that is used in organic synthesis and inhibits the growth of certain fungi.
2. Any of various derivatives of this compound, such as thiabendazole, used especially as anthelmintic and antifungal agents.

benzimidazole

A family of broad-spectrum antiparasitics (abendazole, mebendazole, thiabendazole) active against nematodes (roundworms, ascariasis, enterobius, hookworm infection, strongyloidiasis, trichuriasis), cestodes (flatworms, cysticercosis, echinococcosis) and protozoa (giardiasis, microsporidiosis); benzimidazole acts by binding free beta-tubulin, inhibiting its polymerisation and the microtubule-dependent uptake of glucose.
 
Adverse effects
Abdominal pain, nausea, vomiting, alopecia, increased aminotransferases, neutropenia.
References in periodicals archive ?
That means the maximum allowable benzimidazole drug residue in an animal sample is many times less than likely to produce any sort of measurable side effect in people.
Reports of benzimidazole resistance are increasing in the literature on veterinary medicine; resistance in canine Ancylostoma caninum hookworm (15) and phylogenetically similar bovine intestinal nematodes (17) was associated with SNPs in the P-tubulin gene, particularly in codon 200 but also in codon 167 and, rarely, in codon 198.
Recently benzimidazole containing compounds such as regioisomers of 5(6)-bromo-1-[(phenyl)sulfonyl]-2-[(4-nitrophenoxy)methyl]-1H-benzimidazole have been reported as an antitubercular agents [13].
We decided to synthesize a series of new optically active Pis bearing benzimidazole pendant groups from an equimolar mixture of dianhydride monomer compound (11) and different diamine derived from amino acids, including isoleucine (lie), valine (Val), methionine (Met), phenylalanine (Phe) (Sch.
Influence of ruminal bypass on the pharmacokinetics and efficacy of benzimidazole antihelmintics in sheep.
They screened more than 2000 compounds to develop agents for use in PET and identified quinoline and benzimidazole as high affinity components of NFTs rather than senile plaques [51].
In this work, two novel organic-inorganic hybrid materials {[(Hbiz).sub.6][[As.sub.2][Mo.sub.18][O.sub.62]]} x [H.sub.2]O (1, biz = benzimidazole) and (dim)[[As.sup.III]][sub.2][As.sup.V][Mo.sup.VII][sub.18][O.sub.62]]] (2, dim = 1,6-bis(imidazol)hexane) have been successfully obtained by using the molybdenum arsenate and different N donor compounds (Figure 1) under hydrothermal conditions and their corresponding antitumor performance was subsequently studied.
Thangarasu, "Development of a predictive model for corrosion inhibition of carbon steel by imidazole and benzimidazole derivatives," Corrosion Science, vol.
Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
Mo et al., "Benzimidazole derivatives: Selective fluorescent chemosensors for the picogram detection of picric acid," The Journal of Organic Chemistry, vol.
Zhang, "Synthesis and characterization of porous polyimide films containing benzimidazole moieties," High Performance Polymers, vol.
Bottger et al., "Efficient fluorescent deep-blue and hybrid white emitting devices based on carbazole/ benzimidazole compound," Journal of Physical Chemistry C, vol.