benzimidazole


Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.

benz·im·id·a·zole

(benz-im-id-ā'zōl),
1. A ring system composed of a benzene ring fused with an imidazole ring; occurs in nature as part of the vitamin B12 molecule.
2. A class of antihelmintic, often used to treat nematodes and cestodes.
Farlex Partner Medical Dictionary © Farlex 2012

benzimidazole

(bĕn′zə-mĭ-dăz′ōl′, -mĭd′ə-zōl′)
n.
1. A heterocyclic compound, C7H6N2, that is used in organic synthesis and inhibits the growth of certain fungi.
2. Any of various derivatives of this compound, such as thiabendazole, used especially as anthelmintic and antifungal agents.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

benzimidazole

A family of broad-spectrum antiparasitics (abendazole, mebendazole, thiabendazole) active against nematodes (roundworms, ascariasis, enterobius, hookworm infection, strongyloidiasis, trichuriasis), cestodes (flatworms, cysticercosis, echinococcosis) and protozoa (giardiasis, microsporidiosis); benzimidazole acts by binding free beta-tubulin, inhibiting its polymerisation and the microtubule-dependent uptake of glucose.
 
Adverse effects
Abdominal pain, nausea, vomiting, alopecia, increased aminotransferases, neutropenia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
That means the maximum allowable benzimidazole drug residue in an animal sample is many times less than likely to produce any sort of measurable side effect in people.
Meat inspectors "just say no " to drugs residues
Reports of benzimidazole resistance are increasing in the literature on veterinary medicine; resistance in canine Ancylostoma caninum hookworm (15) and phylogenetically similar bovine intestinal nematodes (17) was associated with SNPs in the P-tubulin gene, particularly in codon 200 but also in codon 167 and, rarely, in codon 198.
Ancylostoma ceylanicum Hookworm in Myanmar Refugees, Thailand, 2012-2015
Recently benzimidazole containing compounds such as regioisomers of 5(6)-bromo-1-[(phenyl)sulfonyl]-2-[(4-nitrophenoxy)methyl]-1H-benzimidazole have been reported as an antitubercular agents [13].
Synthesis, Characterization, Antitumor, Antibacterial and Urease Inhibitory Activity of a Small Series of N-tosyl benzimidazoles
We decided to synthesize a series of new optically active Pis bearing benzimidazole pendant groups from an equimolar mixture of dianhydride monomer compound (11) and different diamine derived from amino acids, including isoleucine (lie), valine (Val), methionine (Met), phenylalanine (Phe) (Sch.
Synthesis and Characterization of Green Membranes Polyimide/Titania Bionanocomposites Containing Amino Acid and Benzimidazole Moieties for Gas Transport Properties
Influence of ruminal bypass on the pharmacokinetics and efficacy of benzimidazole antihelmintics in sheep.
Haemonchosis en una ternera raza Brahman en el tropico alto del Nordeste Antioqueno
They screened more than 2000 compounds to develop agents for use in PET and identified quinoline and benzimidazole as high affinity components of NFTs rather than senile plaques [51].
Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences
In this work, two novel organic-inorganic hybrid materials {[(Hbiz).sub.6][[As.sub.2][Mo.sub.18][O.sub.62]]} x [H.sub.2]O (1, biz = benzimidazole) and (dim)[[As.sup.III]][sub.2][As.sup.V][Mo.sup.VII][sub.18][O.sub.62]]] (2, dim = 1,6-bis(imidazol)hexane) have been successfully obtained by using the molybdenum arsenate and different N donor compounds (Figure 1) under hydrothermal conditions and their corresponding antitumor performance was subsequently studied.
Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver Cancer
Thangarasu, "Development of a predictive model for corrosion inhibition of carbon steel by imidazole and benzimidazole derivatives," Corrosion Science, vol.
Electrochemical Studies of Monoterpenic Thiosemicarbazones as Corrosion Inhibitor for Steel in 1 M HCl
Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
Development of RP-HPLC Method for the Simultaneous Quantitation of Levamisole and Albendazole: Application to Assay Validation
Mo et al., "Benzimidazole derivatives: Selective fluorescent chemosensors for the picogram detection of picric acid," The Journal of Organic Chemistry, vol.
New Ni-Anthracene Complex for Selective and Sensitive Detection of 2,4,6-Trinitrophenol
Zhang, "Synthesis and characterization of porous polyimide films containing benzimidazole moieties," High Performance Polymers, vol.
Synthesis and Characterization of Semicrystalline Polyimides Containing Bridged Linkages
Bottger et al., "Efficient fluorescent deep-blue and hybrid white emitting devices based on carbazole/ benzimidazole compound," Journal of Physical Chemistry C, vol.
Novel Imidazole Substituted Bodipy-Based Organic Sensitizers in Dye-Sensitized Solar Cells

Medical browser ?
Full browser ?