benzimidazole


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benz·im·id·a·zole

(benz-im-id-ā'zōl),
1. A ring system composed of a benzene ring fused with an imidazole ring; occurs in nature as part of the vitamin B12 molecule.
2. A class of antihelmintic, often used to treat nematodes and cestodes.

benzimidazole

(bĕn′zə-mĭ-dăz′ōl′, -mĭd′ə-zōl′)
n.
1. A heterocyclic compound, C7H6N2, that is used in organic synthesis and inhibits the growth of certain fungi.
2. Any of various derivatives of this compound, such as thiabendazole, used especially as anthelmintic and antifungal agents.

benzimidazole

A family of broad-spectrum antiparasitics (abendazole, mebendazole, thiabendazole) active against nematodes (roundworms, ascariasis, enterobius, hookworm infection, strongyloidiasis, trichuriasis), cestodes (flatworms, cysticercosis, echinococcosis) and protozoa (giardiasis, microsporidiosis); benzimidazole acts by binding free beta-tubulin, inhibiting its polymerisation and the microtubule-dependent uptake of glucose.
 
Adverse effects
Abdominal pain, nausea, vomiting, alopecia, increased aminotransferases, neutropenia.

benzimidazole

a group of compounds with anthelmintic properties. They all have the same central chemical structure—1,2-diaminobenzene. Some of the better known pharmaceutical compounds are thiabendazole, albendazole, cambendazole, fenbendazole, mebendazole, oxfendazole, oxibendazole and parbendazole.
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References in periodicals archive ?
1989) Genetic and molecular analysis of a Caenorhabditis elegans O-tubulin that conveys benzimidazole sensitivity.
Comprehensive functional genomics using Caenorhabditis elegans as a model organism
Antifungal activity of organic and organometallic derivatives of benzimidazole and benzothiazole.
In vitro anti-Candida albicans activity of new thiatriazole derivative agents
A single peak is observed at 2[theta] = 27[degrees], which corresponds to parallel benzimidazole ring forming a stacked structure of ABPBI [13, 14].
Phosphoric acid doped poly(2,5-benzimidazole)-based proton exchange membrane for high temperature fuel cell application
Seven benzimidazole pesticides combined at sub-threshold levels induce micronuclei in vitro.
Ex vivo assessment of testicular toxicity induced by carbendazim and iprodione, alone or in a mixture
Belomoina, "High temperature proton exchange membranes based on poly(arylene ether)s with benzimidazole side groups for fuel cells," Journal of Materials Chemistry, vol.
Polymer electrolyte membrane fuel cell performance of a sulfonated poly(arylene ether benzimidazole) copolymer membrane
Resistance to two wormers was considered to be low but of the other two, 78% were resistant to Benzimidazole and 34% were resistant to Levamisole.
Spreading the word about drug resistance
It looked at 47 Welsh farms and the effectiveness of four types of wormer: Benzimidazole (1-BZ); Levamisole (2-LV); Ivermectin (3-ML) and Moxidectin (3-ML).
'Act now to slow down resistance to wormers'
A 3-day course of benzimidazole is the anthelminthic drug of choice.
Bloody diarrhea associated with hookworm infection in traveler returning to France from Myanmar
One of the solutions contains a precise ratio of amino phenyl benzimidazole and paraphenylene diamine dihydrochloride.
Aramid polymerization
The egg hatch test was initially developed for the diagnosis of benzimidazole resistance helminths.
In vitro Ovicidal and Wormicidal Activity of Six Medicinal Plants against Haemonchus contortus
Dioxybenzone(X) Phenyl benzimidazole Homosalate# sulfonic acid (WS)# Meradimate (A)# Sulisobenzone(X) Ecamsule *(1) (A)(WS)# Titanium dioxide (A) Octocrylene# Trolamine salicylate(X)(WS) Octinoxate# Zinc oxide (A)# * 1-Approved in L'Oreal formulations only.
Formulating sunscreens with new tea ingredients
Wang, X, Yang, H, Cao, P, Zhang, Z, "Study of the Adsorption of Benzimidazole and 2-Mercaptobenzothiazole on an Iron Surface by Confocal Micro-Raman Spectroscopy.
Protective behaviors of 2-mercaptobenzothiazole intercalated Zn-Al-layered double hydroxide coating

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