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1. A ring system composed of a benzene ring fused with an imidazole ring; occurs in nature as part of the vitamin B12 molecule.
2. A class of antihelmintic, often used to treat nematodes and cestodes.
1. A heterocyclic compound, C7H6N2, that is used in organic synthesis and inhibits the growth of certain fungi.
2. Any of various derivatives of this compound, such as thiabendazole, used especially as anthelmintic and antifungal agents.
benzimidazoleA family of broad-spectrum antiparasitics (abendazole, mebendazole, thiabendazole) active against nematodes (roundworms, ascariasis, enterobius, hookworm infection, strongyloidiasis, trichuriasis), cestodes (flatworms, cysticercosis, echinococcosis) and protozoa (giardiasis, microsporidiosis); benzimidazole acts by binding free beta-tubulin, inhibiting its polymerisation and the microtubule-dependent uptake of glucose.
Abdominal pain, nausea, vomiting, alopecia, increased aminotransferases, neutropenia.
a group of compounds with anthelmintic properties. They all have the same central chemical structure—1,2-diaminobenzene. Some of the better known pharmaceutical compounds are thiabendazole, albendazole, cambendazole, fenbendazole, mebendazole, oxfendazole, oxibendazole and parbendazole.