Few examples are benoxaprofen
, cerivastatin, cisapride, domperidone (injectable), valdecoxib, and sibutramine.
troglitazone, bromfenac, pemoline, tolcapone, trovafloxacin and benoxaprofen
Earlier to this, benoxaprofen identified as a dual COX/5-LOX inhibitor was withdrawn because it was found to induce severe hepatic and other toxicities .
Parke, "A retrospective study of the molecular toxicology of benoxaprofen," Toxicology, vol.
Examples of multiple claimants' product liability cases that have been brought in the United Kingdom include: Opren (Benoxaprofen
) arthritis drug case; tranquillizer claims (Benzodiazepine); whooping cough cases (Pertussis); African asbestos group action; HIV contaminated blood transfusion claims; and MMR claims.
The PG inhibitors used by them were aspirin (acetylsalicylic acid), indomethacin, and benoxaprofen. The results were the following: Cortisol at 4.1 x [10.sup.-5] M significantly increased both radicle length and the number of secondary roots.
The general lack of any measurable growth or development response to the three inhibitors (aspirin, indomethacin, and benoxaprofen) could be due to a lack of PG biosynthesis in developing mung bean seedlings or to a reserve of PG in the seed with the possible result that no new synthesis of PG occurred over the short duration of the experiments.
Witness the case of the antiarthritis drug Oraflex (benoxaprofen
), withdrawn by manufacturer Eli Lilly & Co.
Thalidomide, ultraviolet radiation, occlusive membranes, benoxaprofen
, and arotinoid acid have all been described as useful treatments in small numbers of selected patients or in individual cases.
This happened in the mid-1980s with the arthritis drug Opren (benoxaprofen
), which was recalled due to dangerous side effects."