benign lymphadenopathy

benign lymphadenopathy

A generic term for any non-malignant regional or generalised enlargement of lymph nodes, which is divisible into histologic patterns. These may include: variably sized germinal centre; polarity of germinal centre; absence of capsular or fat invasion; mitotic activity confined to the germinal centre; cortical localization of germinal centre; or inhomogeneous distribution of follicles.

benign lymphadenopathy

Any non-malignant regional or generalized enlargement of lymph nodes. See Lymph node necrosis.
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In this study among 114 patients 44% of the patients had a benign aetiology, 20% had a malignant aetiology and 34% were normal, 8% had benign lymphadenopathy and another 8% had malignant lymphadenopathy.
The present study consisted of 75 patients, with the highest number of patients 12 (30%) in from the age group of 21-30 years in the cases of benign lymphadenopathy, in rest of age group incidence remains the same.
The most frequently encountered diagnostic factors among patients with benign lymphadenopathy were.
Florid follicular hyperplasia, the initial morphology seen in progressive HIV-related benign lymphadenopathy, is characterized by large, irregularly shaped geographic follicles, covering up to two-thirds of the cross-sectional area of the lymph node, surrounded by an attenuated to absent mantle cell zones (Figure 1).
The progressive stages of HIV-related benign lymphadenopathy (FFH [right arrow] MX [right arrow] FI [right arrow] lymphocyte depletion) correlate with the immune status of the patient and parallel the progressive loss of CD4+ T cells, increasing viral load, and collapse of the immune system.
The most common causes of benign lymphadenopathy are infectious mononucleosis, toxoplasmosis & tuberculosis, may be in the reverse order in the Indian scenario.
Human herpesvirus-8 DNA sequences in human immunodeficiency virus-negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy with giant germinal center hyperplasia and increased vascularity.
112 of 186 (63%) patients with benign lymphadenopathy had a non- specific or reactive etiology.

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