In this study among 114 patients 44% of the patients had a benign aetiology, 20% had a malignant aetiology and 34% were normal, 8% had benign lymphadenopathy
and another 8% had malignant lymphadenopathy.
The present study consisted of 75 patients, with the highest number of patients 12 (30%) in from the age group of 21-30 years in the cases of benign lymphadenopathy
, in rest of age group incidence remains the same.
The most frequently encountered diagnostic factors among patients with benign lymphadenopathy
Florid follicular hyperplasia, the initial morphology seen in progressive HIV-related benign lymphadenopathy, is characterized by large, irregularly shaped geographic follicles, covering up to two-thirds of the cross-sectional area of the lymph node, surrounded by an attenuated to absent mantle cell zones (Figure 1).
The progressive stages of HIV-related benign lymphadenopathy (FFH [right arrow] MX [right arrow] FI [right arrow] lymphocyte depletion) correlate with the immune status of the patient and parallel the progressive loss of CD4+ T cells, increasing viral load, and collapse of the immune system.
The most common causes of benign lymphadenopathy
are infectious mononucleosis, toxoplasmosis & tuberculosis, may be in the reverse order in the Indian scenario.
871 cases (85.22%) were of benign lymphadenopathy
, of which 357 cases (34.93%) were of reactive nature (including 125 cases with activated histiocytic clusters) and 402 cases (39.33%) were tubercular.
Human herpesvirus-8 DNA sequences in human immunodeficiency virus-negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy
with giant germinal center hyperplasia and increased vascularity.
112 of 186 (63%) patients with benign lymphadenopathy
had a non- specific or reactive etiology.