beclin 1

beclin 1

An evolutionarily conserved protein involved in regulating autophagy, development, tumour suppression, vacuolar protein sorting, and required for the abcission step in cytokinesis. It may play a role in antiviral host defence. Atg6/Beclin 1 may function as a VPS and autophagy protein as part of a complex with Class-III PI3 kinase, Vps34.
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Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis.
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.
After Ulk1 complex activation, vesicle nucleation occurs via activation of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex, which comprises PtdIns3K, Beclin 1, Vps15, and Atg14L.
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.
Beclin 1 is the human homolog of BEC-1, has been shown to be monoallelically deleted in up to 75 percent of human cancers.
47 Hepatitis B Virus X Protein Sensitizes Cells to Starvation-Induced Autophagy via Up-regulation of Beclin 1 Expression###91
Zheng, "Aberrant Beclin 1 expression is closely linked to carcinogenesis, differentiation, progression, and prognosis of ovarian epithelial carcinoma," Tumor Biology, vol.
The molecular mechanism of ER-mediated autophagy is accurately regulated by Beclin 1 as well as ER membrane bound protein Bax inhibitor 1 (BI-1).
The study, led by Beth Levine, director of the Center for Autophagy Research and a Howard Hughes Medical Institute investigator, revealed that EGFR turns off autophagy, a process by which cells recycle unneeded parts, by binding to a protein, Beclin 1, which normally turns on the process.
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.
They found RNA evidence of decreased levels of the protein beclin 1 in the hippocampus of schizophrenia patients, a brain region central to learning and memory.