(redirected from becaplermin gel)


(be-kap-lerm-in) ,


(trade name)


Therapeutic: wound ulcer decubiti healing agent
Pharmacologic: platelet derived growth factors
Pregnancy Category: C


Treatment of lower extremity diabetic neuropathic ulcers extending to subcut tissue or beyond and having adequate blood supply.


Promotes chemotaxis of cells involved in wound repair and enhances formation of granulation tissue.

Therapeutic effects

Improved healing.


Absorption: Minimal absorption (<3%).
Distribution: Action is primarily local.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile (improvement in ulcer healing)

Topicalwithin 10 wkunknownunknown


Contraindicated in: Known hypersensitivity to becaplermin or parabens;Known neoplasm at site of application;Wounds that close by primary intention.
Use Cautiously in: Known malignancy; Obstetric / Lactation / Pediatric: Safety not established.

Adverse Reactions/Side Effects


  • erythematous rash at application site


  • malignancy (may lead to ↑ mortality, especially with use of ≥3 tubes) (life-threatening)


Drug-Drug interaction

None known.


Topical (Adults) Length of gel in inches from 15- or 7.5-g tube = length × width of ulcer area × 0.6; from the 2-g tube = length × width of ulcer area × 1.3. Length of gel in centimeters from 15- or 7.5-g tube = length × width of ulcer area ÷ 4; from the 2-g tube = length × width of ulcer area ÷ 2; for 12 hr each day.


Gel: 100 mcg/g (0.01%) in 2-, 7.5-, and 15-g tubes

Nursing implications

Nursing assessment

  • Assess size, color, drainage, and skin surrounding wound at weekly or biweekly intervals. Amount of gel to be applied is recalculated based on wound size.

Potential Nursing Diagnoses

Impaired tissue integrity (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)


  • Topical: Calculated amount is applied as a thin layer (1/16-in. thick) and covered with a moist saline dressing for 12 hr; dressing is removed, ulcer rinsed and redressed with moist dressing without becaplermin for rest of day. Process is repeated daily.
    • Store gel in refrigerator; do not freeze. Do not use beyond expiration date on crimped end of tube.

Patient/Family Teaching

  • Instruct patient on proper technique for application. Wash hands before applying gel and use cotton swab or tongue depressor to aid in application. Tip of tube should not come in contact with ulcer or any other surface; recap tightly after each use. Squeeze calculated amount of gel onto a clean, firm, nonabsorbable surface (wax paper). Spread gel with swab or tongue depressor over the ulcer surface in an even layer to the thickness of a dime. Cover with a saline-moistened gauze dressing.
    • Do not apply more than calculated amount; has not been shown to be beneficial. If a dose is missed, apply as soon as remembered. If not remembered until next day, skip dose and return to regular dosing schedule. Do not double doses.
    • After 12 hr, rinse ulcer gently with saline or water to remove residual gel and cover with saline-moistened gauze.
  • Emphasize the importance of strict wound care and non–weight-bearing program.

Evaluation/Desired Outcomes

  • Improved healing of ulcers. If the ulcer does not decrease in size by 30% within 10 wk or if complete healing has not occurred within 20 wk, continuation of therapy should be reassessed.
Drug Guide, © 2015 Farlex and Partners


A cicatrizant gel containing recombinant PDGF, which may improve wound healing—it stimulates migration of cells to ulcer sites, and prompts tissue growth to heal deep open wounds.
Diabetic foot ulcers.
Expensive, increased risk of cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Becaplermin Wound care An agent used to manage diabetic neuropathic leg ulcers that extend into the dermis or beyond and have an adequate blood supply. See Diabetic ulcer.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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References in periodicals archive ?
In a study of acute wounds inflicted in healthy volunteers, those who received becaplermin gel every day or every other day.
In the first 3 days, every-other-day application of becaplermin gel had the fastest healing rate, followed by becaplermin gel daily application and then bacitracin.
Becaplermin Gel Combined with Surgical Debridement, Relationship of Frequency of Debridement to Ulcer Healing, by Center
In another study comparing becaplermin gel and placebo gel,[41] becaplermin gel (0.01 [micro]g) significantly increased the incidence of complete healing by 43% (50% becaplermin vs 35% placebo; P=.007) and decreased the time to achieve complete healing by 32% (P = .0133).