congenital hypertrophy of the retinal pigment epithelium

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congenital hypertrophy of the retinal pigment epithelium



A thickening of the retinal pigment epithelium present at birth. The thickening appears on funduscopic examination as an oval, black, clearly demarcated lesion within which there are atrophic areas surrounded by a halo that has no pigment. It has been associated with and has been considered to be an ocular marker of familial adenomatous polyposis.

retinal pigment epithelium, congenital hypertrophy of the (CHRPE) 

A benign congenital proliferation of the retinal pigment epithelium which may appear unilaterally as a dark-grey or black, round or oval lesion in the fundus (typical form) or in other cases as multiple smaller lesions grouped together and resembling 'bear tracks'. In atypical form the lesions are bilateral. The latter is associated with familial adenomatous polyposis (an inherited condition characterized by neoplasms derived from epithelial tissue which appear as polyps throughout the rectum and colon and may become malignant) and its variants, Turcot syndrome (neuroepithelial tumours in the central nervous system) or Gardner's syndrome (soft tissue tumours).
References in periodicals archive ?
A closer look in the dirt by the head provided the answer: bear tracks.
Fears for his safety have increased after bear tracks were seen in the area.
No time for breakfast, just a heady adrenaline rush when word spread that the landing party had discovered fresh polar bear tracks.
Grizzlies had attacked three people in recent weeks, very serious maulings, and we found bear tracks while scouting geese.
There were fresh polar bear tracks in the snow so our armed rangers advised us not to stray too far when we arrived from Quest for Adventure at Magdalena Bay in the Arctic.
We followed bear tracks on snow in spring during 1992 and 1995-1998 for a total of 743 km and recorded 15 attacks on moose.
Re the article on Peripheral Retinal Degenerations (OT September 30, p4448), with all due respect to the authors of this article, I would be grateful if you could clarify the section on CHRPE and FAR In the article it states that 'When CHRPE are found in groups, known as bear tracks, it is worth .
We found ourselves in a hushed, Narniaesque world, with bear tracks criss-crossing the pine forest, branches creaking under layers of snow and Lake Tahoe's sparkling waters, far below, reflecting the peaks of the Sierra Nevada range.
I zigzagged back and as I walked, I glanced down and realized that there were fresh bear tracks that were covering my steps.
We stopped briefly to watch a pair of nesting sandhill cranes, then again to examine huge bear tracks in the mud.
This was the first day we came across polar bear tracks, in fact, we found two types.
Across a snowfield, bear tracks recede into the distance, a reminder that field science isnAAEt for wimps.