Bcr-abl oncoprotein | definition of bcr-abl oncoprotein by Medical dictionary
bcr-abl oncoprotein A protein product of the fused BCR-ABLl oncogene produced by the Philadelphia chromosome, which plays a key role in initiating and maintaining leukaemia.
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References in periodicals archive
Imatinib is a 2-phenylaminopyrimidine compound that inhibits the BCR-ABL oncoprotein
found in CML cells .
Chronic myeloid leukemia (CML) is a myeloproliferative disease that originates in an haemopoietic stem cell as a result of t (9; 22) translocation, giving rise to the Ph (Philadelphia chromosome) and Bcr-Abl oncoprotein
. The disease starts in a chronic phase, but as a result of genomic instability, it progresses over time to the accelerated phase and then to blast crisis, becoming increasingly resistant to therapy.
Most importantly, the BCR-ABL oncoprotein
provided, for the first time, a specific therapeutic target in hematologic malignancies.
The Bcr-Abl oncoprotein
differs from the endogenous c-Abl protein in both its subcellular localization and its tyrosine kinase (TK) activity.