bcr-abl oncoprotein

bcr-abl oncoprotein

A protein product of the fused BCR-ABLl oncogene produced by the Philadelphia chromosome, which plays a key role in initiating and maintaining leukaemia.
References in periodicals archive ?
Chronic myeloid leukemia (CML) is a myeloproliferative disease that originates in an haemopoietic stem cell as a result of t (9; 22) translocation, giving rise to the Ph (Philadelphia chromosome) and Bcr-Abl oncoprotein.
Most importantly, the BCR-ABL oncoprotein provided, for the first time, a specific therapeutic target in hematologic malignancies.
The Bcr-Abl oncoprotein differs from the endogenous c-Abl protein in both its subcellular localization and its tyrosine kinase (TK) activity.