bcl-2


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BCL-2

An oncogene that inhibits apoptosis.

Bcl-2

A 25 kDa inner mitochondrial membrane protein which inhibits apoptosis, thus increasing the survival of cells (good or bad). The t(14;18) translocation results in a hybrid bcl-2/immunoglobulin heavy chain transcript consisting of the 5’ half of the bcl-2 mRNA fused to a truncated immunoglobulin heavy chain mRNA.

Normal expression
It is normally expressed by small B lymphocytes of the mantle and marginal zones and by many T cells.

Abnormal expression
Bcl-2 is over expressed in follicular lymphomas with the translocation t(14;18)(q32;q21), detected in 70 to 95% of follicular lymphomas and 20% of diffuse large B cell lymphomas. Expression is greater in grade I than in grade III follicular lymphomas.

BCL-2

An oncogene that inhibits apoptosis.

bcl-2

Proto-ONCOGENEs. This gene is over-expressed in various tumours, especially non-Hodgkin lymphoma, resulting in resistance to APOPTOSIS (programmed cell death) with encouragement of tumour growth. Antisense nucleotide sequences (oligonucleotides) targeted at BCL-2 messenger RNA reduces the expression of BCL-2 and increases apoptosis in these tumours with clinical improvement.
References in periodicals archive ?
The BCL-2 protein family: Opposing activities that mediate cell death.
Bu siniftaki inhibitorler icin kullanilan Bcl-2 inhibitor terimi, hucre yasamini tesvik eden protein ailesi uyelerini baglayan ilaclari kapsamaktadir.
Conclusion: Ferulic acid could significantly descend osteosarcoma cell viability through the promoting apoptosis pathway in which FA activates both caspase-3 and Bax and inactivates Bcl-2.
20] P53 is a protein which has a role in the repairment of DNA, apoptosis, and cycle cell, [26] whereas Bcl-2 is a protein of anti-apoptotic activity.
The aim of current study was to observe the intensity of caspase-3, lipid peroxidation Bcl-2 mRNA, and Glutathione, in MDCK cell lysates after the treatment through AFB1 and the protection exerted through beta-carotene.
To this end, Jurkat cells stably transfected with Bcl-2 or the empty control vector were irradiated with 0, 5, or 10 Gy by 6 MV photons.
Bcl-2 presence has been reported in areas of cholangiolar proliferation and focally, in hepatocytes in patients with cirrhosis caused by HCV.
BAX was the first identified P53-regulated, proapoptotic Bcl-2 family member.
Results showed that telomerase and Bcl-2 expression was significantly lower in group C compared with group B (0.
Dentre alguns fenomenos que geralmente regulam esses processos, podemos citar genes pro e antiapoptoticos da familia BCL-2, mecanismos de detoxificacao intracelular e super-expressao de moleculas que transportam as drogas para fora da celula ou para outros compartimentos celulares, como a glicoproteina-p (produto do gene MDR-1); alem de sistemas de reparo do DNA associados com a familia do TP53.
The study findings potentially could refine this approach so that chemotherapy can be timed more effectively, killing off cancer cells and preventing a relapse when the BCL-2 gene is sufficiently weak.
1) In this regard, B Cell CLL/lymphoma-2 protein (bcl-2), which is an anti-apoptotic member of the bcl-2 protein family, has been implicated as a key player in the neuroprotective actions of lithium (2) and the pathophysiology of BD.