basophilic stippling


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Related to basophilic stippling: Heinz bodies, Pappenheimer bodies, target cells

basophilic stippling

A finding in Wright-Giemsa-stained RBCs that appear as “blue” dots, spots and blots within RBCs, consisting of:
(1) RNA granules—coarse stippling due to RNA instability in young RBCs, seen in lead poisoning (lead inhibits ALA dehydrogenase and ferrochetolase, impairing haeme incorporation and inhibiting nucleotidase), defective HbC or HbE synthesis, sideroblastic or megaloblastic anaemia, thalassemia major and minor, preleukaemic states and pyrimidine 5’-nucleotidase deficiency;
(2) Aggregates of precipitated ribosomes—fine stippling, resulting in diffuse polychromasia secondary to increased RBC production in thalassemia, malabsorption and pernicious anaemia.
References in periodicals archive ?
Basophilic stippling of erythrocytes was found on blood film.
Basophilic stippling is seen with long-term lead exposure.
Tests revealed microcytic anemia, moderate basophilic stippling, and no identifiable source of blood loss.
A subsequent blood film revealed basophilic stippling, a classic sign of lead poisoning.
On investigation Hb was 4g/dl, TLC was 7400/[mm.sup.3], DLC was P66/L/30/M1/E3, Platelets was 1,60,000/[mm.sup.3], Peripheral smear was suggestive of hemolysis with erythroblast 28%, severely microcytic hypochromic, basophilic stippling and polychromasia, Iron studies were normal (Serum Iron of 100mg%, TIBC of 280mg%, and S.
Similarly, basophilic stippling on a blood smear with or without anemia can be seen on a routine laboratory evaluation, but it is neither a sensitive nor a specific finding.
On initial neurologic examination, the child had extreme lethargy with facial palsy and gasping respirations, consistent with lead encephalopathy; laboratory results revealed severe lead toxicity and hematologic abnormalities blood lead level [BLL] 144 [micro]g/dL; erythrocyte protoporphyrin level 593 [micro]g/dL; hemoglobin 8.1; and basophilic stippling).
The polychromatic red cells showed fine basophilic stippling, randomly distributed throughout the cell, with variable numbers of blue inclusions within each cell (Figures 1-4).
Basophilic stippling is often present and nucleated red blood cells are generally seen (2).