Mechanisms other than histamine release which have been implicated in CSU include autoimmunity and abnormalities in basophil signal transduction and basopenia
High UAS7 score (OR: 1.09; CI 95%: [1.03-1.15]) and basopenia (OR: 6.77; CI 95%: [2.01-22.75]) were associated with the requirement of high-dose H1-AH in children with chronic urticaria.
Disease severity and basopenia were risk factors for the requirement of high-dose H1-antihistamines.
Eosinophilia (>400/|[mu]L) was found in 43 patients and basopenia (<20[mu]L) was found in 55 (23.9%).
Various abnormalities in basophils of chronic urticaria patients have been reported like basopenia
, paradoxical suppression of FceRI-mediated release of histamine from basophils, imbalance between positive and negative regulators of signaling through FceRI.
is well documented and basophil numbers are inversely related to urticaria severity .
ochrocephala de Basofilos, sin embargo, segun FUDGE (1997) la Monocitopenia y la Basopenia
son normales para la mayoria de especies.
As with lymphocytes and eosinophils, a decrease in the basophil count (basopenia
) occurs with an increase in adrenal steroids (Corbett, 2000; Kee, 1999).