These breakthroughs in basic protein
research will inevitably lead to a deeper understanding of the development of disease and potential improvements to current disease treatment strategies.
found ADEM to be characterized by IgG autoantibodies targeting myelin basic protein
, proteolipid protein, myelin-associated oligodendrocyte basic glycoprotein and alpha-B-crystallin, whereas MS was characterized by IgM autoantibodies targeting myelin basic protein
, proteolipid protein, myelin-associated oligodendrocyte basic glycoprotein, and oligodendrocyte specific protein.
The human myelin basic protein
gene is included within a 179-kilobase transcription unit: Expression in the immune and central nervous systems.
PB2 97 MF630450 PB1 97 MF630451 PA 97 KP285492 HA 97 KP417103 NP 98 LC050632 NA 94 AB545596 MP 99 CY146719 NS 98/99 LC070024 * HA, hemagglutinin; MP, matrix protein; NA, neuraminidase; NP, nucleoprotein; NS nonstructural; PA, polymerase; PB1, polymerase basic protein
1; PB2, polymerase basic protein
The researchers found that myelin basic protein
and glial fibrillary acidic protein levels were elevated at baseline and through consolidation.
Antibodies against a variety of neural antigens such as amyloid [beta] proteins and peptides (1-42), tau protein, asialoganglioside [GM.sub.1], S100B, glial fibrillary acidic protein (GFAP), rabaptin-5 (rab-5), adenosine triphosphate synthase (ATP-synthase), myelin basic protein
(MBP), and many others known as autoantigens in Alzheimer's disease (AD) are detected in the sera or cerebrospinal fluids (CSF) of patients with AD [2, 8].
In this pathology, eosinophil infiltration releases a number of cationic proteins, including the major basic protein
(MBP) and the eosinophil cationic protein (ECP), which can lead to the damage of the bronchial epithelial cells.
A defective immune system, specifically triggered and propelled by cytotoxic T cells against target organs including gastrointestinal tract (inflammatory bowel disease), synovial cartilage (rheumatoid arthritis), uveal membrane (anterior uveitis), myelin basic protein
(multiple sclerosis), bone marrow (aplastic anemia) etc.
Studies have shown that Loss of nerve fibers, myelin abnormalities and significant decrease in the expression of myelin basic protein
occur in DPN (Vinik & Mehrabyan, 2004; Miranda-Massari, 2011).
Boggs, "Myelin basic protein
: A multifunctional protein," Cellular and Molecular Life Sciences, vol.
At the beginning a basic protein
structure is translated from a DNA sequence followed by changes in the structure of basic protein
called posttranslational modifications.5,6After formulation of basic protein
its quality control, purification and production of end product requires some strict parameters including control of temperature, pH, agitation and types of containers used.