Shaped like the letter "C," these compounds wrap around chains of lysine, a basic amino acid
that is a constituent of most proteins.
When a basic amino acid
is in an acidic medium (having a pH lower than 7 and containing the hydrogen ion [H.
The creme's active ingredients include arginine, a basic amino acid
known to dilate and engorge blood vessels, effectively plumping the G-spot area making it easier to locate.
The HA gene of KU-08 contained multiple basic amino acid
insertions at the HA cleavage site (SPQRERRRKKRR), similar to those found at the HA cleavage site for other viruses characterized from Thailand during this time.
The switch from a low pathogenic avian influenza (LPAI) phenotype, common in wild birds and poultry, to the HPAI phenotype is achieved by the introduction of basic amino acid
residues into the HA0 cleavage site (5).
992), including 1 change in the HA cleavage site, resulting in a unique arginine (R) > lysine (K) replacement, which contains 6 basic amino acid
residues KRRKKR, whereas all Thai isolates from 2003 and 2004 have RRRKKR.
Although the cleavage site adjacent to the fusion peptide is typically a basic amino acid
, the reported Angrem52 cDNA sequence has an acidic glutamic acid at this position (Figure 1B).
Hu444 is likely not pathogenic in chickens, which is consistent with previous observations that a basic amino acid
at -4 is required for cleavage (5).
The Chilean HPAI isolates were unusual not only because of the size of the insert but also because the viruses were highly pathogenic with only three basic amino acids
near the cleavage site (-1, -4, and -6 positions) for the first HPAI viruses in the outbreak, although a substitution occurred later in the outbreak, resulting in an additional basic amino acid
at the -3 position.
The connecting peptide of HA contained an insertion of 4 basic amino acids
(arginine-arginine-arginine-lysine), which is the same as in the HA of A/duck/Korea/Buan2/2014 (H5N8), an isolate from a duck farm in South Korea (GenBank accession no.
Detoxification of peach kernels led to an improved amino acid profile, with the detoxified meal having a higher percentage of essential, aromatic, sulphur and basic amino acids
, while the undetoxified meal had a higher proportion of the non-essential and acid amino acids.
Basic amino acids
include L-lysine (L-Lys), L-arginine (L-Arg) and L-histidine (L-His), in chickens, these three amino acids are nutritionally essential and are involved in several metabolic pathways.