Only 1 basic amino acid
(PQIATR*G) was found at the HA cleavage site of A/canine/Taiwan/E01/2014.
The percentage of total neutral amino acid (TNAA) ranged from 54.9-56.3, indicating that they formed the bulk of the amino acids; total acidic amino acid (TAAA) ranged from 27.2-27.4% which were far lower than % TNAA, whilst the percentage range in total basic amino acid
(TBAA) was 15.6-17.9, which made them the third largest group among the samples.
In some microtubule plus end tracking proteins, there are some basic amino acid
serine rich sequences.
Aromatic and basic amino acid
increased in percentage as we go from psychrophiles to thermophiles.
Percentage of the essential, acidic, basic and neutral amino acids of dehulled African nutmeg (Monodora myristica), (mg/g crude protein) Amino acids Crude protein Percentage (mg/g) Total amino acid 648.90 100 Total non-essential amino acid 335.0 51.60 Total essential amino acid with histidine 313.90 48.40 Total essential amino acid without histidine 292.0 44.90 Total Acidic amino acid 157.80 24.30 Total basic amino acid
97.80 15.10 Total neutral amino acid 393.30 60.60
Shaped like the letter "C," these compounds wrap around chains of lysine, a basic amino acid
that is a constituent of most proteins.
As has been indicated, a positive charge on a basic amino acid
residue (found in lysine, arginine, histidine) is destroyed in an alkaline medium.
The sequence of predominantly basic amino acids
is generally designated by the formula B ([X.sub.7]) B, where B is arginine or lysine, and X is any non-acidic amino acid; there is also at least one additional basic amino acid
within, or adjacent to, the basic unit (7, 8).
The HA gene of KU-08 contained multiple basic amino acid
insertions at the HA cleavage site (SPQRERRRKKRR), similar to those found at the HA cleavage site for other viruses characterized from Thailand during this time.
The HA gene of KU-02 and KU-03 contained multiple basic amino acid
insertions at the HA cleavage site (SPQRERRRKKRR) as well as glutamine and glycine (Q222-G224) at the receptor binding site.
The switch from a low pathogenic avian influenza (LPAI) phenotype, common in wild birds and poultry, to the HPAI phenotype is achieved by the introduction of basic amino acid
residues into the HA0 cleavage site (5).
AY651328; identity score 0.992), including 1 change in the HA cleavage site, resulting in a unique arginine (R) > lysine (K) replacement, which contains 6 basic amino acid
residues KRRKKR, whereas all Thai isolates from 2003 and 2004 have RRRKKR.