base-substitution mutation

A point mutation resulting in the replacement of one nitrogenous base in DNA for another.

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base analogue

References in periodicals archive ?

Previous studies in this laboratory have shown that daunomucin and adriamycin can induce frameshift (i.e., TA98) and GC to AT base-substitution mutations (i.e., TA7004) in the bacterium Salmonella typhimurium (Mackay et al.

Mutagenic activity of idarubicin and epirubicin in the bacterium Salmonella typhimurium

In addition, adriamycin can also induce frameshift and/or base-substitution mutations in prokaryotic (McCann et al.

Previous studies indicated that adriamycin induced frameshift (i.e., TA98) and base-substitution mutations (i.e., TA100) in the bacterium Salmonella typhimurium (McCann et al.

THE INDUCTION OF GC TO AT TRANSITION MUTATIONS WITH ADRIAMYCIN IN THE BACTERIUM SALMONELLA TYPHIMURIUM

Prior to this study, it was not known if daunomycin could induce base-substitution mutations. Thus, one could not rule out the possibility that these events might occur in the cytotoxic range in Salmonella.

The mutagenic effects of anthracyclines in the bacterium Salmonella typhimurium: induction of transition mutations with daunomycin