base-substitution mutation

base-substitution mutation

A point mutation resulting in the replacement of one nitrogenous base in DNA for another.
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Previous studies in this laboratory have shown that daunomucin and adriamycin can induce frameshift (i.e., TA98) and GC to AT base-substitution mutations (i.e., TA7004) in the bacterium Salmonella typhimurium (Mackay et al.
In addition, adriamycin can also induce frameshift and/or base-substitution mutations in prokaryotic (McCann et al.
Previous studies indicated that adriamycin induced frameshift (i.e., TA98) and base-substitution mutations (i.e., TA100) in the bacterium Salmonella typhimurium (McCann et al.
Prior to this study, it was not known if daunomycin could induce base-substitution mutations. Thus, one could not rule out the possibility that these events might occur in the cytotoxic range in Salmonella.