Previous studies in this laboratory have shown that daunomucin and adriamycin can induce frameshift (i.e., TA98) and GC to AT base-substitution mutations
(i.e., TA7004) in the bacterium Salmonella typhimurium (Mackay et al.
In addition, adriamycin can also induce frameshift and/or base-substitution mutations in prokaryotic (McCann et al.
Previous studies indicated that adriamycin induced frameshift (i.e., TA98) and base-substitution mutations (i.e., TA100) in the bacterium Salmonella typhimurium (McCann et al.
Prior to this study, it was not known if daunomycin could induce base-substitution mutations
. Thus, one could not rule out the possibility that these events might occur in the cytotoxic range in Salmonella.