Base stacking | definition of base stacking by Medical dictionary
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base stacking The stacking of nucleotide base pairs in parallel planes at the interior of a helical double-stranded nucleic acid.
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This method takes advantage of the premise that base stacking
stabilizes DNA hybridization such that matched reporter binding is preferentially more stable than mismatched reporter binding (4).
provides the flexibility needed for the capture and reporter oligo probes when working with amplicons (small replicating DNA fragments) of varying length.
The bulge size is a major determinant of the destabilization caused by the disturbed base stacking