base pair


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Related to base pair: DNA, complementary base pairing

base pair (b.p., bp),

the complex of two heterocyclic nucleic acid bases, one a pyrimidine and the other a purine, brought about by hydrogen bonding between the purine and the pyrimidine; base pairing is the essential element in the structure of DNA proposed by J. Watson and F. Crick in 1953; usually guanine is paired with cytosine (G·C), and adenine with thymine (A·T) or uracil (A·U).

base pair

n.
A pair of nitrogenous bases, consisting of a purine linked by hydrogen bonds to a pyrimidine, that connects the complementary strands of DNA or of hybrid molecules joining DNA and RNA. The base pairs are adenine-thymine and guanine-cytosine in DNA, and adenine-uracil and guanine-cytosine in RNA.

base pair

The structure formed between 2 complementary nitrogenous bases—purines and pyrimidines—which are hydrogen-bonded (guanine and cytosine share 3 hydrogen bonds; adenine and thymine share 2) to form double-stranded nucleic acids—DNA or RNA.

BPs are held together by weak hydrogen bonds; in double-stranded nucleic acids (DNA, RNA), purines (adenine and guanine) bond to their complementary opposites, pyrimidines (cytosine thymine, uracil)—under normal circumstances, adenine binds to thymine (DNA) or to uracil (RNA), and guanine binds to cytosine (DNA and RNA).

base pair

(bās pār)
The complex of two heterocyclic nucleic acid bases, one a pyrimidine and the other a purine, brought about by hydrogen bonding between the purine and the pyrimidine; base pairing is the essential element in the structure of DNA. Usually guanine is paired with cytosine (G·C), and adenine with thymine (A·T) or uracil (A·U). The sequence of the complementary bases in either strand of a two-stranded DNA molecule codes for amino acids used in the manufacture of proteins. Trios of bases (codons) specify each of 20 amino acids. During protein synthesis (translation), messenger RNA and ribosomes read the order of amino acids from strings of DNA to create protein chains, which are then released into the cell.

base pair

Two linked molecules, one a purine the other a pyrimidine, that lie across between the two strands of the DNA double helix. The bases are linked by easily-broken hydrogen bonds and the linkage occurs only in a particular, complementary, way-adenine with thymine and guanine with cytosine. This is the essence of DNA replication, which starts with the separation of a length of the two strands at bonds. In RNA, uracil replaces thymine and adenine links with it. Distance along a DNA sequence is measured as the number of base pairs.

base pair (bp)

in double-stranded NUCLEIC ACID molecules, a pair of complementary NUCLEOTIDES: in DNA, A-T and G-C; in RNA, A-U and G-C, with one nucleotide contributed from each strand of the DUPLEX. The pair of bases is held together by HYDROGEN BONDS. The length of a double-stranded nucleic acid molecule is measured in base pairs. See also COMPLEMENTARY BASE PAIRING.
References in periodicals archive ?
The Amz121 structure and G-C or A-T base pairs had binding energy from 251.51 kJ/mol to 314.62 kJ/mol which were very strong.
Therefore, the Oz:G base pair was significantly more thermodynamically stable than the Oz:A, Oz:C, or Oz:T base pair.
For all of these reasons, a two-unnatural base pair system of the s-y and s-z pairs could be used as a coupled transcription and translation system for the site-specific incorporation of non-standard amino acids into proteins.
Thousands of these base pairs come together to form the DNA chain.
Base Pair will use the investment to acquire new lab instruments and other technology that will allow the company to expand its cellular and molecular analysis capabilities, enabling improved methods for finding aptamers that bind targets on and in live cells.
The Hoogsteen base pairs typically show up when DNA is acted upon by a protein or damaged by chemical insults, according to Al-Hashimi.
When two DNA single strands can align with each other, each of the H-bonds that can form between the correct A:T and G:C base pairs has a small attractive energy.
Around 3,000 children from Cheshire and Staffordshire helped to build the base pairs for the rest of the molecule and the finished product will be on show throughout National Science Week.
Add in another base pair, and the number of potential words increases to 216.
Because technicians must participate in the reading, gel sequencing is relatively expensive, costing $1 or more per base pair. However, a new DNA polymerase, licensed by the British firm Amersham Intl.
Illumina's test will sequence every single base pair in a person's DNA, scanning huge quantities of genetic data that are not currently understood.
When they applied a voltage between the tip and the metal surface, electrons started flowing, crossing a single base pair from side to side.