base deletion

base deletion

removal of a NUCLEOTIDE base, a purine or a pyrimidine from the DNA structure, producing a DELETION MUTATION that can have serious consequences for the related protein. See FRAMESHIFT.
References in periodicals archive ?
The exonic single base deletion mutations in patients FA82, FA121 and FA199 all resulted in frameshift mutations.
The CF mutation is a good example of the effect of base deletion on the sequence of amino acids in the protein.
Insertion mutations and single base deletions were rarely observed with Cpf1, but out-of-frame mutation frequencies were comparable with SpCas9 [60].
The frequency of base substitution and small deletions including single base deletions and deletions < 1 kb formed in fiber-treated MEF cells was only 2-fold higher than those from nontreated cases.