basaloid carcinoma

cloacogenic carcinoma

1. a type of squamous cell carcinoma of the anus originating in tissues arising from, or in remnants of, the cloaca.
2. in oncology, anal cancer arising proximal to the pectinate line.
[cloaca + -genic]

basaloid carcinoma

Gastrointestinal
A subtype of squamous cell carcinoma arising at the anorectal transition zone, which comprises 20% of all anal carcinomas. It is linked to HPV infection and more common in homosexual males, implicating anal intercourse as a vector. It has been variously reported as having either a better or worse prognosis than standard anal cancer.
 
Lung
A form of large cell carcinoma (non-small cell type), in which at least 50% of the cellular component is a basal cell carcinoma; it is often high-grade with 15–50 mitoses/10 HPF, and has a dismal prognosis by some authors as a type of squamous cell carcinoma.

IHC
p63, CK 5/6 +ve.

DiffDx
Poorly differentiated squamous cell carcinoma, small cell carcinoma, large cell neuroendocrine carcinoma.
 
Pattern
Small cuboidal or fusiform cells; lobular or tentacular invasion, peripheral palisading.
 
Prognosis
Probably worse than stage-matched squamous cell carcinoma.

Oral
Aggressive, rapidly growing; nodes are involved in 2/3 at time of diagnosis; distant metastases frequent (37–50%); age/site/stage/treatment matched-case control studies have the same prognosis as high-grade conventional SCC.
References in periodicals archive ?
Rare cutaneous metastasis from a probable basaloid carcinoma of the colon mimicking pyogenic granuloma.
However, BerEP4 was found to be unable to distinguish BCC from trichoepithelioma, trichoblastoma, Merkel cell carcinoma, and basaloid carcinoma. Conflicting results have also been reported regarding BerEP4 use in differentiating BCC from Bowen's Disease.
One patient with basaloid carcinoma developed multiple metastasis in liver and adrenals.
Squamous cell carcinoma and basaloid carcinoma can be differentiated from SNUC by the absence of keratinization in SNUC.
Four patients had malignancy of anal canal (2.6%); out of these 2 had squamous cell carcinoma (50%), 1 had adenocarcinoma (25%) and 1 (25%) had basaloid carcinoma.
Last FU 1 2 months 2 Lost to FU 3 1 month 4 1 (Thoracic 1 month and lumbar vertebrae) Table 8: Local Recurrence Histopathology stage after APR Region Involved [T.sub.3][N.sub.2] B/L inguinal [M.sub.0] obturator, common (Dukes' C) iliac lymph nodes + severe Hydronephrosis (treated by PCN) Anaplastic Recurrent lesion malignancy adherent to posterior urinary bladder wall [T.sub.3][N.sub.2] Perineal region [M.sub.0] [T.sub.2][N.sub.0] Perineal region + [M.sub.0] Vaginal involvement Basaloid carcinoma Vulva (Vulvectomy performed) [T.sub.3][N.sub.2] Paraaortic and R.
INTRODUCTION: Adenoid cystic carcinoma (Basaloid carcinoma, Cylindroma) though frequently associated with salivary glands can also occur at other sites of the body with a exocrine secretory glandular function like the maxillary sinus, tracheobronchial tree, nasopharynx, breast, prostate, lungs and the uterine cervix.
(3) Uncommon specific cell types, such as large cell neuroendocrine carcinoma, basaloid carcinoma, and lymphoepithelioma-like carcinoma, are now removed from the large cell carcinoma category, and clear cell and rhabdoid variants are no longer considered histologic subtypes.
(10) There were only 2 cases of basaloid carcinoma in our study comprising of 0.93% of all microscopic types.
Uncommon specific cell types (large cell neuroendocrine carcinoma, basaloid carcinoma, and lymphoepithelioma-like carcinoma) are no longer classified under large cell carcinoma.
INTRODUCTION: Basaloid carcinoma is an uncommon variant of squamous cell carcinoma, first identified by Wain et al in 1986, and described as "highly malignant variant of squamous cell carcinoma with a basaloid pattern".