basaloid carcinoma

cloacogenic carcinoma

1. a type of squamous cell carcinoma of the anus originating in tissues arising from, or in remnants of, the cloaca.
2. in oncology, anal cancer arising proximal to the pectinate line.
[cloaca + -genic]

basaloid carcinoma

[bā′səloid]
Etymology: Gk, basis + eidos, form, karkinos, crab, oma, tumor
a rare transitional malignant neoplasm of the anal canal containing areas that resemble basal cell carcinoma of the skin. Basaloid carcinoma is rapidly invasive. Tumor may spread to the skin of the perineum.

basaloid carcinoma

Gastrointestinal
A subtype of squamous cell carcinoma arising at the anorectal transition zone, which comprises 20% of all anal carcinomas. It is linked to HPV infection and more common in homosexual males, implicating anal intercourse as a vector. It has been variously reported as having either a better or worse prognosis than standard anal cancer.
 
Lung
A form of large cell carcinoma (non-small cell type), in which at least 50% of the cellular component is a basal cell carcinoma; it is often high-grade with 15–50 mitoses/10 HPF, and has a dismal prognosis by some authors as a type of squamous cell carcinoma.

IHC
p63, CK 5/6 +ve.

DiffDx
Poorly differentiated squamous cell carcinoma, small cell carcinoma, large cell neuroendocrine carcinoma.
 
Pattern
Small cuboidal or fusiform cells; lobular or tentacular invasion, peripheral palisading.
 
Prognosis
Probably worse than stage-matched squamous cell carcinoma.

Oral
Aggressive, rapidly growing; nodes are involved in 2/3 at time of diagnosis; distant metastases frequent (37–50%); age/site/stage/treatment matched-case control studies have the same prognosis as high-grade conventional SCC.
References in periodicals archive ?
Other 2 are basaloid carcinoma, micro-invasive carcinoma.
3) Uncommon specific cell types, such as large cell neuroendocrine carcinoma, basaloid carcinoma, and lymphoepithelioma-like carcinoma, are now removed from the large cell carcinoma category, and clear cell and rhabdoid variants are no longer considered histologic subtypes.
Squamous cell carcinoma and basaloid carcinoma can be differentiated from SNUC by the absence of keratinization in SNUC.
6%); out of these 2 had squamous cell carcinoma (50%), 1 had adenocarcinoma (25%) and 1 (25%) had basaloid carcinoma.
Uncommon specific cell types (large cell neuroendocrine carcinoma, basaloid carcinoma, and lymphoepithelioma-like carcinoma) are no longer classified under large cell carcinoma.
0] Vaginal involvement Basaloid carcinoma Vulva (Vulvectomy performed) [T.
Bahrami et al (96) studied PLAG1 expression by immunostaining and PLAG1 gene rearrangement by fluorescence in situ hybridization (FISH) in 22 carcinoma ex pleomorphic adenomas along with 39 cases representing various benign and malignant salivary gland neoplasms: adenocarcinomas, not otherwise specified (4 cases); mucoepidermoid carcinomas (8 cases); adenoid cystic carcinomas (7 cases); salivary duct carcinomas (4 cases); epithelial-myoepithelial carcinomas (2 cases); polymorphous low-grade adenocarcinoma (1 case); myoepithelial carcinoma (1 case); adenoid cystic carcinoma (1 case); basaloid carcinoma (1 case); pleomorphic adenomas (5 cases); basal cell adenomas (4 cases); and low-grade salivary gland neoplasm, not otherwise specified (1 case).
84 Total 110 105 215 100 Table 8: Histological type of Malignancy involving colorectal region Site / Caceum Ascending Transverse Descending Microscopic type Colon Colon Colon Adneocarcinoma 11 7 5 4 Mucinous Carcinoma 7 11 5 5 Saquamous -- -- -- -- Carcinoma Adenosquamous -- -- -- -- Carcinoma Signet ring 2 -- -- -- Cell Carcinoma Melanoma -- -- -- -- Basaloid Carcinoma -- -- -- -- Carcinoid -- -- -- -- Non Hodgkins 1 1 -- -- Lymphoma Metastasis 1 2 2 -- Total 22 22 12 9 Site / Sigmoid Rectum Total Percentage Microscopic type Colon (%) Adneocarcinoma 20 66 113 52.
17,18) Basaloid carcinoma of the lung is an uncommon poorly differentiated NSCLC, probably akin to SCC.
INTRODUCTION: Basaloid carcinoma is an uncommon variant of squamous cell carcinoma, first identified by Wain et al in 1986, and described as "highly malignant variant of squamous cell carcinoma with a basaloid pattern".
To test the utility of this protocol, we identified 3 additional cases of basaloid carcinoma, of unknown primary, metastatic to neck lymph nodes (Table 5).
In moderately differentiated basaloid carcinoma, palisading, is less prominent, whilst in poorly differentiated cases cells are formed into small highly infiltrative clumps and there is considerable nuclear pleomorphism and mitotic activity.