basal-cell nevus syndrome

basal-cell nevus syndrome

n.
An inherited syndrome marked by the presence of numerous basal-cell carcinomas of the skin, cysts of the jawbones, erythematous pitting of the palms and soles, and often skeletal anomalies. Also called Gorlin's syndrome.
References in periodicals archive ?
There is, therefore, cumulative DNA damage leading to mutations, apart from the mutagenesis, overexposure to sunlight depresses the local immune system, and possibly decreasing immune surveillance for new tumor cells, it also develops as a result of Basal-Cell Nevus Syndrome, or Gorlin Syndrome, which is also characterized by Keratocystic odontogenic tumors of the jaw, (6) palmar or plantar (Sole of the foot) pits, calcification of the falx cerebri (in the center line of the brain) and rib abnormalities.
Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome.
The second publication, entitled "Inhibiting the Hedgehog Pathway in Patients with Basal-Cell Nevus Syndrome," reports on results from an investigator-sponsored study evaluating the potential of Erivedge in 41 patients with basal cell nevus syndrome (BCNS) and surgically eligible BCCs.
Presence of dural calcifications in children should raise the suspicion of underlying pathology, mainly basal-cell nevus syndrome.
Classically, calcifications are described in tuberous sclerosis and Sturge-Weber syndrome but can also be seen in neurofibromatosis and basal-cell nevus syndrome.