In fact, a significant increase in the upper abdominal sensations such as epigastric pressure, epigastric fullness, and nausea has previously been demonstrated in obese patients with abnormal esophageal exposure to acid, suggesting that the increased esophageal acid exposure in these patients might potentiate the perception of a different concurrent stimulus, such as barostat
Animals were administrated with test drugs, and after an equilibration period intrabag pressure was increased with 2-mmHg increments every 3 min, starting from the minimal distending pressure up to 16 mmHg without deflating the barostat
bag at each pressure step.
The prospective, longitudinal barostat
study of 101 patients also found that increased rectal compliance was not related to treatment failure.
Early results show decreased sensitivity to balloon distention in a barostat
They used an electronic barostat
to monitor the volume of air in the stomachs of 10 obese patients and 11 healthy volunteers.
The simulations were performed in the isothermic-isobaric ensemble at a temperature of 310 K maintained by a v-rescale thermostat  with a coupling constant of 0.25 ps and a 1 atm pressure maintained by a Parrinello--Rahman barostat
 with a coupling constant of 1 ps.
In all simulations a Berendsen barostat
with the relaxation constant of 5 ps was used for semi-isotropic pressure coupling.
Apart from gastric emptying, which mainly reflects antral motility, a small study using gastric barostat
showed increased gastric accommodation in patients with cirrhosis .
Previous studies, selecting the visceral stimuli of a barostat
as a stressful trigger to assess visceral hypersensitivity in IBS, report increased attention via dorsal anterior cingulate cortex (ACC) towards pain sensation in IBS versus healthy controls , as well as impaired inhibitory control of rectal pain in emotional-sensory regulatory areas including amygdala, insula, and thalamus, as well as primary and secondary sensory cortex .
In a more recent double-blind and sham-controlled study the primary outcome was the barostat
distensibility test of the gastroesophageal junction before and after administration of sildenafil.