The Rheos[TM]
Baroreflex Hypertension Therapy[TM] System, developed by Minneapolis-based CVRx, Inc.
Keith Ferdinand, MD, will present and analyze the implications of the most recent clinical trial data evaluating renal sympathetic denervation and
baroreflex activation therapy for treating resistant hypertension.
The ongoing study is assessing the safety and clinical efficacy of the Rheos[TM]
Baroreflex Hypertension Therapy[TM] System, an implantable device for the treatment of hypertension in patients who cannot control their blood pressure with medications and lifestyle modifications.
The EAP Designation applies to CVRx's Phase III randomized, controlled clinical trial,
Baroreflex Activation Therapy for Heart Failure Pivotal Clinical Trial (BeAT-HF).
The complications associated with OSAS, such as increased sympathetic activity oxidative stress, changes in
baroreflex mechanisms and changes in vascular function, may render patients more prone to cardiovascular diseases (14).
In people with essential hypertension, breathing 6 breaths per minute improves arterial
baroreflex sensitivity (BRS) and lowers blood pressure.
In general, 5-min SDNN, r-MSSD, HF, and TP largely reflect vagal tone, whereas LF is related to
baroreflex function (Goldstein et al.
Chronic
baroreflex activation effects on sympathetic nerve traffic,
baroreflex function and cardiac haemodynamics in heart failure: a proof of concept study.
2006) Heat stress enhances arterial
baroreflex control of muscle sympathetic nerve activity via increased sensitivity of burst gating, not burst area, in humans.
Gastrodin improved
baroreflex sensitivity and increased gammaamino butyric acid content in brains without decreasing blood pressure in spontaneously hypertensive rats.
My associates and I published results 2 years ago showing that deep breathing can improve the blunted
baroreflex sensitivity often seen in patients with diabetes (Diabetologia 2011;54:1862-70).
04%, LNa) and, therefore, in a prehypertensive state, Gordon and Mark (10,13) demonstrated a partial arterial baroreceptor impairment (vs Dahl SR rats on a LNa diet) that translated into a diminution of both the heart rate (HR) and the neurosympathetic-mediated hindlimb vascular resistance
baroreflex sensitivities, without altering the baseline MAP.
